Eplerenone + Statins for Heart Disease in HIV
(SUNRISE HIV Trial)
What You Need to Know Before You Apply
What is the purpose of this trial?
HIV has transitioned to a chronic disease in which well-treated persons remain at higher risk for heart disease when compared to the general population. Statin medications have been shown to reduce the number of events related to heart disease, but there are still individuals who will have complications from heart disease despite statin use. This study is being conducted to determine whether adding on another medication to statins called eplerenone, which has been shown to reduce inflammation in the heart vasculature among persons with HIV, can further decrease the risk of heart disease in HIV through its anti-inflammatory and blood pressure-lowering potential.
Are You a Good Fit for This Trial?
This trial is for people living with HIV who are already taking statins to lower cholesterol but still have a higher risk of heart disease. Participants should not have conditions or be on medications that would make eplerenone unsafe for them.Inclusion Criteria
Exclusion Criteria
What Are the Treatments Tested in This Trial?
Interventions
- Eplerenone
Trial Overview
The study tests if adding eplerenone (a blood pressure and anti-inflammatory drug) to standard statin therapy can further reduce inflammation in the arteries compared to a placebo, using a randomized design.
How Is the Trial Designed?
2
Treatment groups
Experimental Treatment
Placebo Group
Patients randomized into the Eplerenone arm will receive 50 mg administered orally twice a day for 12 months.
Patients randomized into the Placebo arm will receive 50 mg administered orally twice a day for 12 months.
Find a Clinic Near You
Who Is Running the Clinical Trial?
Massachusetts General Hospital
Lead Sponsor
University of California, Los Angeles (UCLA Health)
Collaborator
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