Celecoxib + Acetaminophen for Postoperative Pain
What You Need to Know Before You Apply
What is the purpose of this trial?
This is an open-label randomized study of approximately 500 pediatric patients (2-18 years of age, weighing more than 10 kg) undergoing adenotonsillectomy. Participants are assigned to a preoperative multimodal analgesic regimen (oral celecoxib the evening before and the morning of surgery, plus intra-operative dexamethasone and acetaminophen) or to standard of care (no pre-operative medication; intra-operative dexamethasone and acetaminophen). The primary aim is to compare postoperative pain control, measured by rescue analgesic consumption, over the first 72 hours after surgery. Secondary aims assess safety (postoperative bleeding and adverse medication events) and feasibility (healthcare utilization and caregiver satisfaction).
Who Is on the Research Team?
Christina Yang, MD
Principal Investigator
NYU Langone Health
Zahrah Taufique, MD
Principal Investigator
NYU Langone Health
Are You a Good Fit for This Trial?
This trial is for children aged 2 to 18 years, weighing over 10 kg, who are scheduled to have their tonsils and adenoids removed (adenotonsillectomy).Inclusion Criteria
Exclusion Criteria
What Are the Treatments Tested in This Trial?
Interventions
- Acetaminophen
- Celecoxib
- Dexamethasone
Trial Overview
The study compares giving celecoxib with acetaminophen before surgery versus just acetaminophen (both groups also get dexamethasone during surgery) to see which approach better controls pain after the operation.
How Is the Trial Designed?
2
Treatment groups
Experimental Treatment
Active Control
Pediatric patients (2-18 years, \>10 kg) undergoing adenotonsillectomy who receive oral celecoxib (6 mg/kg, max 100 mg) the evening before surgery and the morning of surgery, plus intra-operative dexamethasone (Decadron) and acetaminophen (Tylenol). Post-operative regimen is the attending's standard of care.
Pediatric patients (2-18 years, \>10 kg) undergoing adenotonsillectomy who receive no pre-operative medication; intra-operative dexamethasone (Decadron) and acetaminophen (Tylenol) only. Post-operative regimen is the attending's standard of care.
Find a Clinic Near You
Who Is Running the Clinical Trial?
NYU Langone Health
Lead Sponsor
Unbiased Results
We believe in providing patients with all the options.
Your Data Stays Your Data
We only share your information with the clinical trials you're trying to access.
Verified Trials Only
All of our trials are run by licensed doctors, researchers, and healthcare companies.