500 Participants Needed

Cross-Training Program for Cancer Survivors

(CAPABLE Trial)

TB
JB
Overseen ByJennifer B Beebe-Dimmer, MPH, PhD.
Age: 18+
Sex: Any
Trial Phase: Academic
Sponsor: Barbara Ann Karmanos Cancer Institute
No Placebo GroupAll trial participants will receive the active study treatment (no placebo)

What You Need to Know Before You Apply

What is the purpose of this trial?

This trial explores how a cross-training exercise program might help cancer survivors improve fitness, body health, and overall quality of life compared to standard guidelines. Participants will engage in a 12-week exercise routine designed to boost physical performance. Individuals diagnosed with cancer, who have their doctor's approval, and can travel to the sessions may qualify, except those with certain advanced cancer conditions or who require mobility aids.

As an unphased trial, this study offers participants a unique opportunity to contribute to innovative research that could enhance cancer recovery strategies.

Will I have to stop taking my current medications?

The trial information does not specify whether you need to stop taking your current medications. It's best to discuss this with your doctor to ensure it's safe to participate.

What prior data suggests that this cross-training program is safe for cancer survivors?

Research has shown that the high-intensity training program used in the CAPABLE study is generally safe for cancer survivors. An earlier study with 48 participants included exercises such as interval training, strength training, and conditioning workouts. Participants managed these exercises well, with no major reports of negative effects or serious risks associated with the program.

While participants might feel tired or sore after workouts, the exercises are not expected to cause harm. The program aims to safely improve fitness and quality of life.12345

Why are researchers excited about this trial?

Researchers are excited about the Cross-Training Program for Cancer Survivors because it introduces a high-intensity exercise regimen tailored specifically for individuals recovering from cancer. Unlike traditional recovery programs that may focus more on gentle physical activity, this program aims to boost overall fitness and potentially improve long-term health outcomes through a structured and challenging exercise routine. By engaging cancer survivors in a more vigorous level of physical activity, researchers hope to uncover new insights into how exercise can aid in recovery and enhance quality of life post-treatment.

What evidence suggests that this cross-training program is effective for cancer survivors?

This trial will test a 12-week exercise program for cancer survivors, focusing on high-intensity functional training. Studies have shown that such programs can help cancer survivors improve fitness and reduce fatigue. Research suggests that high-intensity functional training, which includes strength exercises and short bursts of intense activity, can enhance physical function and appearance. Early results indicate that participants in these programs feel less exhausted and more energetic. This method is being tested to determine if it offers more benefits than the current recommendations from the American Cancer Society for cancer survivors.12467

Who Is on the Research Team?

JB

Jennifer Beebe-Dimmer, MPH, PhD.

Principal Investigator

Barbara Ann Karmanos Cancer Institute

Are You a Good Fit for This Trial?

This trial is for cancer survivors who are 18 or older and have been diagnosed with invasive cancer. They must be cleared by their doctor to join the program, which could include those currently in treatment or those who've finished. Participants need a way to get to the facility on session days.

Inclusion Criteria

Cleared from their physician to participate in the program (We assume that most patients will have completed treatment, however if a patient is currently under treatment, this should be their oncologist. If the patient is not currently undergoing treatment, this could be primary care physician or oncologist).
I have a way to get to and from the clinic on my appointment days.
I have been diagnosed with a cancer that is spreading into surrounding tissues.

Timeline for a Trial Participant

Screening

Participants are screened for eligibility to participate in the trial

2-4 weeks

Treatment

Participants undergo a 12-week high-intensity functional training program to improve functional performance, body composition, and quality of life

12 weeks
Weekly surveys and monthly physical assessments

Follow-up

Participants are monitored for safety and effectiveness after treatment

4 weeks

What Are the Treatments Tested in This Trial?

Interventions

  • 12 week pilot intervention study
Trial Overview The study tests a 12-week cross-training program against current American Cancer Society guidelines for cancer survivors. It aims to see if this new approach can better improve functional performance, body composition, and quality of life.
How Is the Trial Designed?
1Treatment groups
Experimental Treatment
Group I: A 12-week pilot intervention study introducing a high-intensiExperimental Treatment1 Intervention

Find a Clinic Near You

Who Is Running the Clinical Trial?

Barbara Ann Karmanos Cancer Institute

Lead Sponsor

Trials
166
Recruited
9,300+

Published Research Related to This Trial

In a study of 3710 postmenopausal breast cancer survivors with an average age of 78.8 years, factors such as higher education, better self-rated health, improved physical functioning, and greater social support were linked to increased participation in physical activity.
Younger survivors (under 75) who received radiation therapy engaged in more physical activity, while older survivors (85 and above) showed a unique trend where those with moderate pain exercised more than those without pain, suggesting that age and pain perception significantly influence physical activity levels.
Correlates of physical activity among older breast cancer survivors: Findings from the Women's Health Initiative LILAC study.Krok-Schoen, JL., Pennell, ML., Saquib, N., et al.[2023]
Theory-based physical activity interventions for overweight and obese female cancer survivors are safe and feasible, with high adherence and retention rates, and they can lead to moderate to large improvements in physical activity, especially when including a center-based component.
Health-related outcomes showed positive effects, such as improvements in aerobic fitness and significant reductions in waist circumference, while only one serious adverse event was reported, indicating a favorable safety profile.
Effects of Theory-Based Behavioral Interventions on Physical Activity Among Overweight and Obese Female Cancer Survivors: A Systematic Review of Randomized Controlled Trials.Rossi, A., Friel, C., Carter, L., et al.[2019]
The BEAT Cancer physical activity intervention significantly improved physical and mental health outcomes in breast cancer survivors, with notable enhancements in SF-36 scores and lower extremity dysfunction after 3 months compared to usual care, involving 222 participants.
Improvements in mental health and vitality were sustained even 3 months after the intervention, indicating long-term benefits, while various factors like baseline health and income influenced the effectiveness of the intervention.
Effects of a multicomponent physical activity behavior change intervention on breast cancer survivor health status outcomes in a randomized controlled trial.Rogers, LQ., Courneya, KS., Carter, SJ., et al.[2018]

Citations

Study Details | NCT03750981 | C.A.P.A.B.L.E. (CrossFit® ...A 12-week pilot intervention study introducing a high-intensity functional training program to 100 cancer survivors and evaluate the effects of this program on ...
CAPABLE Study RegistrationThis program runs for 12 weeks and is free to qualifying cancer survivors. Exercises include interval training, strength training and conditioning workouts.
Effects of a pilot 12-week exercise program on breast ...Perceived physical fatigability improves after an exercise intervention among breast cancer survivors: A pilot randomized clinical trial.
C.A.P.A.B.L.E. (Cross-Training and Physical ActivityA 12-week pilot intervention study introducing a high-intensity functional training program to 100 cancer survivors and evaluate the effects of ...
Every Day Counts: a randomized pilot lifestyle intervention ...A randomized pilot trial designed for women with metastatic breast cancer (MBC) framed by the American Cancer Society nutrition and physical activity (PA) ...
The impact of high intensity interval training in a diverse ...The CAPABLE study is a single-arm, pilot exercise intervention that introduced 48 cancer survivors to a high intensity interval and strength training program.
Free Fitness Classes for Cancer Survivors Return to ...12 weeks of exercise training for free. These classes are provided as part of Cross-Training and Physical Activity: A Better Life Experience (CAPABLE).
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