CBD and THC for Substance Abuse

(THC-REDUX Trial)

This trial aims to examine how CBD, a compound from cannabis, affects the impact of THC, another cannabis compound, in regular cannabis users. Participants will receive various combinations of CBD and THC or a placebo to compare effects. The trial seeks individuals who have inhaled cannabis at least once a week in the past month and are not currently seeking treatment for cannabis use. As a Phase 1 trial, the research focuses on understanding how the treatment works in people, offering participants a unique opportunity to be among the first to receive this new treatment combination.

The trial information does not specify whether you need to stop taking your current medications. It's best to discuss this with the study team to get a clear answer.

Previous studies have shown that CBD does not appear to be addictive or lead to dependence in people. However, some individuals have reported side effects such as sleepiness and fatigue. In a safety review, 79% of participants experienced some side effects, with 25% feeling drowsy. Concerns exist that CBD might interact with other medications and cause liver problems.

Research suggests that THC can lead to addiction in about 22% to 30% of users. It may also cause relationship issues or reduce life achievements.

Researchers are excited about using CBD and THC for substance abuse because these compounds offer a natural approach that could target addiction differently from traditional treatments. Unlike existing options, which often include medications like methadone or buprenorphine, CBD and THC are derived from cannabis and may help manage cravings and withdrawal symptoms without the stigma or side effects associated with opioid treatments. Specifically, CBD is being investigated for its potential to reduce anxiety and stress, which are common triggers for substance use. This natural approach could provide a fresh alternative to current therapies, potentially reshaping how substance abuse is treated.

Research has shown that CBD, one of the treatments in this trial, may help reduce the desire for drugs, including THC, potentially assisting with substance abuse issues. Studies have found that CBD can make drug use less appealing and help control cravings. In this trial, some participants will receive CBD alone, while others will receive a combination of CBD and THC. Using CBD with THC can help reduce withdrawal symptoms and cravings. This combination might also improve mood and reduce anxiety, making it easier to cut down on substance use. Overall, these findings suggest that CBD, either alone or with THC, could effectively treat substance abuse problems.⁴⁶⁷⁸⁹