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Psilocybin for Effects Study

CA
Overseen ByCarlos A Zamarripa, PhD
Age: 18+
Sex: Any
Trial Phase: Phase 1
Sponsor: Johns Hopkins University

What You Need to Know Before You Apply

What is the purpose of this trial?

This study will evaluate the subjective and behavioral effects of psilocybin relative to placebo and alcohol.

Who Is on the Research Team?

CA

Carlos A Zamarripa, PhD

Principal Investigator

Johns Hopkins University

Are You a Good Fit for This Trial?

This trial is for healthy adults who do not have major medical or psychiatric conditions and are not taking medications that could interact with psilocybin or alcohol. Participants should not have a history of substance abuse or be pregnant.

Inclusion Criteria

I am not pregnant or breastfeeding.
Have vital signs in normal range
Have not donated blood in past 30 days
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Exclusion Criteria

I am currently taking medications or supplements that could affect my safety in this study.
History or current evidence of significant medical condition impacting safety (e.g., hypertension, epilepsy)
Family history of first degree relative with psychotic disorder or bipolar 1 disorder
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What Are the Treatments Tested in This Trial?

Interventions

  • Psilocybin

Trial Overview

The study tests different doses of psilocybin (including placebo) and compares their effects to those of alcohol on mood, behavior, and potential for misuse. Participants receive capsules with varying amounts of psilocybin and drinks with either no alcohol or enough to reach legal intoxication.

How Is the Trial Designed?

6

Treatment groups

Experimental Treatment

Active Control

Placebo Group

Group I: 5mg Psilocybin + 0.00% BACExperimental Treatment1 Intervention
Group II: 25mg Psilocybin + 0.00% BACExperimental Treatment1 Intervention
Group III: 1mg Psilocybin + 0.00% BACExperimental Treatment1 Intervention
Group IV: 15mg Psilocybin + 0.00% BACExperimental Treatment1 Intervention
Group V: 0mg Psilocybin + 0.08% BACActive Control1 Intervention
Group VI: 0mg Psilocybin + 0.00% Blood Alcohol Content (BAC)Placebo Group1 Intervention

Find a Clinic Near You

Who Is Running the Clinical Trial?

Johns Hopkins University

Lead Sponsor

Trials
2,366
Recruited
15,160,000+

National Institute on Drug Abuse (NIDA)

Collaborator

Trials
2,658
Recruited
3,409,000+

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