MOON101 for Peanut Allergy

(SURVEYOR Trial)

This trial explores the safety of a new treatment called MOON101 for individuals with peanut allergies. Researchers aim to determine if MOON101, which delivers tiny amounts of peanut allergen through the skin, causes any side effects and to identify the highest dose that can be tolerated without severe reactions. Participants will receive both MOON101 and a placebo (a treatment with no active ingredient) to compare effects. Individuals with a doctor-confirmed peanut allergy who react quickly after consuming peanuts might be suitable candidates. As a Phase 1 trial, this research focuses on understanding how the treatment works in people, offering participants the opportunity to be among the first to receive this new treatment.

Yes, you may need to stop taking certain medications. You cannot use β-blockers, ACE inhibitors, ARBs, or calcium channel blockers during the trial. You also need to temporarily stop antihistamines and topical steroids before specific tests.

Research shows that MOON101 remains in the early stages of human safety testing. Detailed safety information from completed studies is not yet available. However, because the trial is in its first phase, researchers prioritize safety and closely monitor the treatment for any side effects. MOON101 is a small patch with tiny needles that introduces small amounts of peanut allergen into the skin, potentially reducing allergy sensitivity over time.

Unlike the current standard treatments for peanut allergies, which often include oral immunotherapy and avoidance strategies, MOON101 introduces a unique delivery method using microneedle stamps. This innovative approach allows for direct application of peanut protein to the skin, potentially reducing the risk of severe reactions seen with oral treatments. Researchers are excited because this method could offer a safer, more controlled way to desensitize individuals to peanuts, with the potential for varying dosages (1ug to 100ug) to cater to different sensitivity levels. This could lead to more personalized and less invasive treatment options for those with peanut allergies.

Research has shown that MOON101, a treatment for peanut allergies, has promising results in animal studies. It uses a tiny needle patch to deliver small amounts of peanut allergens directly into the skin. This method aims to reduce the allergic reaction to peanuts over time. Early studies have found MOON101 to be as effective as treatments like EpiPen in managing peanut allergies. Although researchers are still studying its effectiveness in people, these early results are encouraging. Participants in this trial will receive different doses of MOON101 to evaluate its effectiveness and safety.¹²⁶⁷⁸