PF-08642534 for Obesity

Age: 18+
Sex: Any
Trial Phase: Phase 1
Sponsor: Pfizer
No Placebo GroupAll trial participants will receive the active study treatment (no placebo)

What You Need to Know Before You Apply

What is the purpose of this trial?

This study will look at a study drug called PF-08642534 in people with obesity (have too much body weight) to see: if participants can take different amounts (doses) of the study drug in a safe way and how adults with obesity tolerate it, and how the body handles the study drug (for example, how the study drug is absorbed and removed from the body).

People who want to join the study will first go through a screening period of up to 4 weeks. Doctors will check if each person meets the study conditions, including age, body weight, and general health. People with certain medical conditions will not be able to take part in the study.

Who Is on the Research Team?

PC

Pfizer CT.gov Call Center

Principal Investigator

Pfizer

Are You a Good Fit for This Trial?

This trial is for adults with obesity who are generally healthy. Participants must meet certain age and weight requirements. People with specific medical conditions or health issues will not be able to join.

Inclusion Criteria

Participants are generally otherwise healthy but may have mild chronic conditions such as dyslipidemia or hypertension
Body mass index (BMI) ≥30.0 and ≤40.0 kg/m² with stable body weight prior to screening

Exclusion Criteria

I have diabetes.
I have a serious heart, liver, kidney, digestive, or mental health disorder.
I have a condition that affects how my body absorbs or processes medications.

What Are the Treatments Tested in This Trial?

Interventions

  • PF-08642534

Trial Overview

The study is testing different doses of a new medicine called PF-08642534 compared to a placebo (inactive substance) in people with obesity, to see how safe it is and how the body processes it.

How Is the Trial Designed?

2

Treatment groups

Experimental Treatment

Group I: PlaceboExperimental Treatment1 Intervention
Group II: PF-08642534Experimental Treatment1 Intervention

Find a Clinic Near You

Who Is Running the Clinical Trial?

Pfizer

Lead Sponsor

Trials
4,712
Recruited
50,980,000+
Known For
Vaccine Innovations
Top Products
Viagra, Zoloft, Lipitor, Prevnar 13

Albert Bourla

Pfizer

Chief Executive Officer since 2019

PhD in Biotechnology of Reproduction, Aristotle University of Thessaloniki

Patrizia Cavazzoni profile image

Patrizia Cavazzoni

Pfizer

Chief Medical Officer

MD from McGill University