Panitumumab-IRDye800 for Ovarian Cancer
What You Need to Know Before You Apply
What is the purpose of this trial?
This is a pilot project to determine the safety and feasibility of using panitumumab-IRDye800 to detect cancerous tissue compared to normal surrounding tissue in participants with ovarian cancer undergoing surgical resection. This study is an extension of the work previously done using this agent in patients with squamous cell carcinoma (SCC) of the head and neck, exploring its utility in a different cancer type.
Who Is on the Research Team?
Teresa Boitano, MD
Principal Investigator
University of Alabama at Birmingham
Are You a Good Fit for This Trial?
This trial is for people with ovarian cancer who are scheduled for surgery to remove tumors. It may also include those with certain types of skin or head and neck cancers, like squamous cell carcinoma. Participants should be healthy enough for surgery.Inclusion Criteria
Exclusion Criteria
What Are the Treatments Tested in This Trial?
Interventions
- Panitumumab-IRDye800
Trial Overview
The study tests if a special imaging agent called Panitumumab-IRDye800 can safely help surgeons see and detect cancer tissue during operations. This is an early-stage (pilot) safety and feasibility study.
How Is the Trial Designed?
1
Treatment groups
Experimental Treatment
Enrolled patients will receive a one-time IV infusion of 50mg of the investigational agent, panitumumab-IRDye800, 24-72 hours prior to the scheduled surgical resection. Participants will be monitored using standard clinical parameters to evaluate for toxicity. Participants will be observed immediately after infusion of the study drug. The following observations and tests shall be performed after treatment to identify both acute and late treatment specific toxicity: vital signs, physical exam, toxicity grading, assignment of performance status, hematology, and blood chemistries (complete metabolic profile to include magnesium and phosphorus). NCI Common Toxicity Criteria v5.0 will be used for grading of toxicity.
Find a Clinic Near You
Who Is Running the Clinical Trial?
University of Alabama at Birmingham
Lead Sponsor
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