Study of Monzosertib In Patients With R/R AML Or High-Risk Myelodysplastic Syndrome

AM
Overseen ByAbhishek Maiti, MBBS
Age: 18+
Sex: Any
Trial Phase: Phase 1
Sponsor: M.D. Anderson Cancer Center
No Placebo GroupAll trial participants will receive the active study treatment (no placebo)

What You Need to Know Before You Apply

What is the purpose of this trial?

The goal of this clinical research study is to find the recommended dose of monzosertib in patients with relapsed/refractory AML and high-risk MDS. The safety and effects of monzosertib will also be studied.

Who Is on the Research Team?

AM

Abhishek Maiti, MBBS

Principal Investigator

UT MD Anderson Cancer Center

Are You a Good Fit for This Trial?

What Are the Treatments Tested in This Trial?

How Is the Trial Designed?

3

Treatment groups

Experimental Treatment

Group I: Arm 3: Phase 1b ESC Arm 3 Treatment - Monzosertib with IsavuconazoleExperimental Treatment2 Interventions
Group II: Arm 2: Phase 1b ESC Arm 2 Treatment - Monzosertib with PosaconazoleExperimental Treatment2 Interventions
Group III: Arm 1: Phase 1b ESC Arm 1 Treatment - Monzosertib with No AzolesExperimental Treatment1 Intervention

Find a Clinic Near You

Who Is Running the Clinical Trial?

M.D. Anderson Cancer Center

Lead Sponsor

Trials
3,107
Recruited
1,813,000+

Carna Biosciences, Inc.

Industry Sponsor

Trials
1
Recruited
120+