MK-1403 for Healthy Subjects
What You Need to Know Before You Apply
What is the purpose of this trial?
The purpose of this trial is to learn about a trial medicine called MK-1403. Researchers designed MK-1403 to treat a type of heart and blood vessel disease called atherosclerotic cardiovascular disease (ASCVD).
Before giving a trial medicine to people with a health condition, researchers first do clinical trials in healthy people. This trial will help researchers learn about the safety of MK-1403 and if participants tolerate it. Tolerate means participants receive the trial medicine and they do not need to stop taking it due to health problems. The trial will also measure what happens to MK 1403 in a healthy person's body over time.
Who Is on the Research Team?
Medical Director
Principal Investigator
Merck Sharp & Dohme LLC
Are You a Good Fit for This Trial?
This trial is for healthy adults with a BMI between 18 and 32 who do not have any significant health problems. Participants should be generally well and meet basic health requirements.Inclusion Criteria
Exclusion Criteria
Timeline for a Trial Participant
Screening
Participants are screened for eligibility to participate in the trial
Treatment
Participants receive MK-1403 formulations under fed and fasted conditions to evaluate bioavailability
Follow-up
Participants are monitored for safety and effectiveness after treatment
What Are the Treatments Tested in This Trial?
Trial Overview
The study is testing two different formulations of a new medicine called MK-1403, which is being developed to treat heart and blood vessel disease. The main goal is to see if the drug is safe and how it behaves in healthy people.
How Is the Trial Designed?
3
Treatment groups
Experimental Treatment
MK-1403 FM 1 + additive tablet administered once orally at study dose after a high-fat meal.
MK-1403 FM2 tablet + additive administered once orally at study dose after a high-fat meal.
MK-1403 FM1 + additive tablet administered once orally at study dose in a fasted state.
Find a Clinic Near You
Who Is Running the Clinical Trial?
Merck Sharp & Dohme LLC
Lead Sponsor
Chirfi Guindo
Merck Sharp & Dohme LLC
Chief Marketing Officer since 2022
Degree in Engineering from Ecole Centrale de Paris, MBA from New York University Stern School of Business
Robert M. Davis
Merck Sharp & Dohme LLC
Chief Executive Officer since 2021
JD from Northwestern University Pritzker School of Law, MBA from Northwestern University Kellogg Graduate School of Management, Bachelor's in Finance from Miami University
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