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MVA-BN-EBV for EBV Infection

BN
Overseen ByBavarian Nordic A/S, MD
Age: 18 - 65
Sex: Any
Trial Phase: Phase 1
Sponsor: Bavarian Nordic

What You Need to Know Before You Apply

What is the purpose of this trial?

Phase 1, single-center, randomized, placebo-controlled, double-blind clinical trial.

Participants (N = 15) will receive a 2-dose schedule (1 vaccination on day 1 and day 28) randomized, receiving either MVA-BN-EBV (n = 12) or placebo (n = 3).

Are You a Good Fit for This Trial?

This trial is for healthy young adults who do not have any serious medical conditions. Participants should not have a history of EBV infection or immune system problems, and must be able to attend all study visits.

Inclusion Criteria

General good health without any clinically relevant medical illness, physical exam findings, or laboratory abnormalities as determined by the PI
Negative HIV antibody test, negative hepatitis B surface antigen, and negative antibody test to hepatitis C virus
Body mass index (BMI) ≥18.5 and ≤35.0
See 5 more

Exclusion Criteria

Pregnancy or breast-feeding
Any condition that creates an unacceptable risk to the participant in the opinion of the investigator
Any condition that will interfere with the conduct of the trial or the validity of the data in the opinion of the investigator
See 21 more

What Are the Treatments Tested in This Trial?

Interventions

  • MVA-BN-EBV

Trial Overview

The study is testing the safety and immune response of an experimental vaccine called MVA-BN-EBV compared to a placebo. Participants are randomly assigned to receive two doses (on day 1 and day 28) in a double-blind manner.

How Is the Trial Designed?

2

Treatment groups

Active Control

Placebo Group

Group I: MVA-BN-EBVActive Control1 Intervention
Group II: PlaceboPlacebo Group1 Intervention

Find a Clinic Near You

Who Is Running the Clinical Trial?

Bavarian Nordic

Lead Sponsor

Trials
67
Recruited
50,900+

Paul Chaplin

Bavarian Nordic

Chief Executive Officer since 2014

PhD in Immunology from Bristol University

Jean-Christophe May

Bavarian Nordic

Chief Medical Officer since 2020

PharmD and MBA

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