BMS-986527 for Kidney Cancer

Not yet recruiting at 16 trial locations
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Overseen ByFirst line of the email MUST contain NCT # and Site #.
Age: 18+
Sex: Any
Trial Phase: Phase 1
Sponsor: Juno Therapeutics, Inc., a Bristol-Myers Squibb Company
No Placebo GroupAll trial participants will receive the active study treatment (no placebo)

What You Need to Know Before You Apply

What is the purpose of this trial?

The purpose of this study is to assess the safety and tolerability of BMS-986527 in participants with Clear Cell Renal Cell Carcinoma (ccRCC)

Who Is on the Research Team?

BS

Bristol-Myers Squibb

Principal Investigator

Bristol-Myers Squibb

Are You a Good Fit for This Trial?

This trial is for adults with clear cell renal cell carcinoma (a type of kidney cancer). Participants should be in generally good health aside from their cancer. People with certain other medical conditions or who are unable to follow the study procedures may not be eligible.

Inclusion Criteria

I have tried or cannot receive standard immunotherapy, but not standard TKI drugs.
I have advanced or metastatic kidney cancer with clear cell features.
I have tumors that can be measured on scans or tests.
See 2 more

Exclusion Criteria

Other protocol-defined Inclusion/Exclusion criteria apply
My cancer came back or did not respond within 12 months of my last immunotherapy.
I have not used certain strong medications that affect drug metabolism recently.
See 1 more

What Are the Treatments Tested in This Trial?

Interventions

  • BMS-986527
  • Cabozantinib
  • Nivolumab

Trial Overview

The study is testing a new drug called BMS-986527, alone or possibly combined with Nivolumab and Cabozantinib, to see if it is safe and tolerable for people with this type of kidney cancer.

How Is the Trial Designed?

3

Treatment groups

Experimental Treatment

Group I: Cohort 3: BMS-986527 with CabozantinibExperimental Treatment2 Interventions
Group II: Cohort 2: BMS-986527 with NivolumabExperimental Treatment2 Interventions
Group III: Cohort 1: BMS-986527 monotherapyExperimental Treatment1 Intervention

Find a Clinic Near You

Who Is Running the Clinical Trial?

Juno Therapeutics, Inc., a Bristol-Myers Squibb Company

Lead Sponsor

Trials
19
Recruited
3,100+

Bristol-Myers Squibb

Industry Sponsor

Trials
2,731
Recruited
4,127,000+
Headquarters
New York City, USA
Known For
Oncology & Cardiovascular
Top Products
Eliquis, Opdivo, Revlimid, Orencia
Christopher Boerner profile image

Christopher Boerner

Bristol-Myers Squibb

Chief Executive Officer since 2023

PhD in Business Administration from the Haas School of Business, University of California, Berkeley; BA in Economics and History from Washington University in St. Louis

Deepak L. Bhatt profile image

Deepak L. Bhatt

Bristol-Myers Squibb

Chief Medical Officer since 2024

MD from Yale University; MSc in Clinical Epidemiology from the University of Pennsylvania