Neurofeedback Training for Aging

(DecidingBrain Trial)

This trial explores how brain training can assist older adults with trust-related decision-making. It focuses on using real-time brain imaging (fMRI) to guide neurofeedback training, enhancing participants' ability to learn trust. This method is known as rtfMRI-guided Neurofeedback Training. Participants are divided into two groups: one receives real feedback, and the other receives simulated feedback (Sham Control). Ideal candidates are older adults who speak English fluently, have at least an 8th-grade education, and maintain a stable medication regimen. As an unphased trial, this study allows participants to contribute to groundbreaking research in cognitive health.

The trial requires that you are on a stable medication regimen, so you won't need to stop your current medications unless they are anticholinergics, anticonvulsants, neuroleptics, sedatives, or other drugs known to affect cognition.

Studies have shown that real-time fMRI neurofeedback training is generally safe for people. Both young and older adults have used this training without major problems. In past studies, participants learned to control certain brain areas using this feedback. Extensive reports of negative side effects or serious safety concerns are absent, suggesting that the treatment is well-tolerated. For those considering joining a trial using this method, existing research supports its safety.¹²³⁴⁵

Researchers are excited about rtfMRI-guided neurofeedback training for aging because it offers a novel approach that directly targets brain activity in real-time. Unlike traditional methods that might involve medication or cognitive exercises, this technique provides immediate visual feedback on brain activity. The contingent neurofeedback arm allows participants to see and potentially influence their own brain activity, which could lead to enhanced cognitive function. This personalized approach is different from current treatments and holds promise for improving brain health in aging populations.

Research shows that real-time brain scans used for feedback can enhance thinking skills as people age. In this trial, participants will receive either contingent rtfMRI neurofeedback training or non-contingent/sham rtfMRI neurofeedback training. One study found that this method improved focus in both young and older individuals. Another study discovered that older adults and those with early signs of Alzheimer's disease had better memory after this training. This technique has also improved behavior in individuals with conditions like schizophrenia and nicotine addiction. These findings suggest that this brain training might help older adults make better decisions by enhancing brain function.²³⁴⁶⁷