Imaging Biomarkers for Lung Cancer
What You Need to Know Before You Apply
What is the purpose of this trial?
This trial aims to explore how lung tumors use sugar for energy, using magnetic resonance imaging (MRI) technology. Participants will receive a special sugar solution through an IV during surgery, allowing researchers to track how the tumor processes sugar. The research focuses on improving imaging techniques, known as imaging biomarkers, to better understand lung cancer. Individuals with a suspected or confirmed lung tumor requiring surgical removal might be a good fit. As an unphased trial, this study offers a unique opportunity to contribute to groundbreaking research that could enhance future lung cancer diagnostics.
Will I have to stop taking my current medications?
The trial protocol does not specify whether you need to stop taking your current medications. However, if you have poorly controlled diabetes, you may not be eligible to participate.
What prior data suggests that this method is safe for evaluating lung tumors?
Research has shown that imaging tools like MRI are generally safe for people. Early results from studies using a special type of MRI called hyperpolarized 13C-MRI, which involves a special sugar, have demonstrated its safety and practicality for patients with various cancers, such as prostate and breast cancer. These studies reported no major safety concerns.
The 13C-glucose used in the study is a slightly altered sugar solution administered through an IV. While specific side effects for this study are not detailed, its use in a trial indicates it has passed safety checks in earlier tests. Prospective participants should discuss any safety concerns or questions with the research team.12345Why are researchers excited about this trial?
Researchers are excited about the Imaging Biomarkers for Lung Cancer trial because it has the potential to transform how we detect and understand lung cancer during surgery. Unlike traditional methods that rely on visual assessment and pathology, this approach uses a 13C-glucose solution administered intravenously. This unique method allows surgeons to see metabolic activity in real-time, providing a more precise picture of tumor tissue. This could lead to more accurate removal of cancerous tissue and possibly improve surgical outcomes, offering a new level of precision in lung cancer treatment.
What evidence suggests that this MRI method is effective for evaluating lung tumors?
Research has shown that special imaging techniques can help evaluate lung cancer. In this trial, participants will receive a 13C-glucose solution intravenously during surgery to assess treatment effectiveness. MRI scans provide clear images of lung tumors and reveal how they use sugar to grow. This method uses a special sugar solution to observe tumor energy use, potentially aiding in planning better treatments. Evidence suggests these imaging techniques could improve treatment outcomes for lung cancer patients.26789
Who Is on the Research Team?
Kemp H Kernstine, MD
Principal Investigator
University of Texas Southwestern Medical Center
Are You a Good Fit for This Trial?
This trial is for adults over 18 with known or suspected malignant lung lesions that need surgical removal. It's open to all races and ethnicities. People with poorly controlled diabetes or those who are not suitable for surgery cannot participate.Inclusion Criteria
Exclusion Criteria
Timeline for a Trial Participant
Screening
Participants are screened for eligibility to participate in the trial
Pre-Surgery Imaging
Participants undergo DCE-MRI to determine eligibility for the [U-13C] glucose infusion
Surgery and Infusion
Participants receive 13C-glucose solution intravenously during surgery for tumor removal
Follow-up
Participants are monitored for metabolic alterations using C-13 isotopomer analysis and metabolomics
What Are the Treatments Tested in This Trial?
Interventions
- Imaging Biomarkers
Find a Clinic Near You
Who Is Running the Clinical Trial?
University of Texas Southwestern Medical Center
Lead Sponsor