Dobutamine for Spinal Cord Injury
(CARDIO-SCI Trial)
What You Need to Know Before You Apply
What is the purpose of this trial?
The first hours-to-day following acute traumatic cervical SCI represent a critical period of time to optimize hemodynamic management. After a spinal cord injury, cardiovascular function is affected. Maintaining blood pressure becomes is an important part of treatment as it supports recovery of the injured spinal cord. Blood pressure is most often increased using vasopressors, such as norepinephrine. Although these drugs help maintain blood flow, they may also lead to increased bleeding in the injury site, making the lesion worse. Alternatively, dobutamine, a medication that helps the heart pump more effectively, has shown to maintain blood pressure and improve prefusion at the injury site. This study will assess dobutamine capacity to maintain blood pressure acutely post injury.
Are You a Good Fit for This Trial?
This trial is for people who have recently suffered a spinal cord injury in the neck or upper back area. Participants must be in the early hours to days after their injury and need help managing their blood pressure.Inclusion Criteria
Exclusion Criteria
What Are the Treatments Tested in This Trial?
Interventions
- Dobutamine
Trial Overview
The study tests dobutamine, a medication that helps the heart pump better, to see if it can safely maintain blood pressure right after spinal cord injury. Patients will receive dobutamine and possibly other standard treatments in a crossover design.
How Is the Trial Designed?
1
Treatment groups
Experimental Treatment
The main procedure in this study is a "cross-over" from NE to DOB, in which we will assess cardiac function while switching the hemodynamic management from NE to DOB.
Find a Clinic Near You
Who Is Running the Clinical Trial?
University of British Columbia
Lead Sponsor
United States Department of Defense
Collaborator
Unbiased Results
We believe in providing patients with all the options.
Your Data Stays Your Data
We only share your information with the clinical trials you're trying to access.
Verified Trials Only
All of our trials are run by licensed doctors, researchers, and healthcare companies.