Semaglutide for Prostate Cancer
What You Need to Know Before You Apply
What is the purpose of this trial?
In this exploratory, single-arm, nonrandomized trial, the impact of the preoperative utilization of the glucagon-like peptide-1 (GLP-1) receptor agonist (RA) semaglutide prior to radical prostatectomy in participants with intermediate risk prostate cancer will be investigated. Semaglutide will be administered according to the FDA-approved label for chronic weight management and participants will be dosed with a weekly subcutaneous injection. The primary aim of this trial is to explore the tumor biological activity of semaglutide in these participants. The trial will also evaluate the safety and tolerability of this preoperative treatment, along with the impact on physiologic/metabolic parameters.
Who Is on the Research Team?
Issac Bowman
Principal Investigator
Banner Health
Are You a Good Fit for This Trial?
This trial is for people with intermediate-risk prostate cancer who are scheduled to have their prostate removed by surgery. Participants should be able to safely receive semaglutide and follow the study procedures.Inclusion Criteria
Exclusion Criteria
What Are the Treatments Tested in This Trial?
Interventions
- Semaglutide
Trial Overview
The study tests weekly injections of semaglutide, a medication usually used for weight management, before prostate removal surgery. It aims to see how the drug affects the tumor and overall health in these patients.
How Is the Trial Designed?
1
Treatment groups
Experimental Treatment
Participants enrolled in this single-arm study will receive weekly subcutaneous semaglutide for 3 to 6 months prior to planned radical prostatectomy. Semaglutide will be administered according to the FDA-approved dosing regimen, with dose titration as tolerated. Treatment will be discontinued one week prior to surgery, after which participants will proceed with standard-of-care radical prostatectomy and postoperative follow-up.
Find a Clinic Near You
Who Is Running the Clinical Trial?
Banner Health
Lead Sponsor
Unbiased Results
We believe in providing patients with all the options.
Your Data Stays Your Data
We only share your information with the clinical trials you're trying to access.
Verified Trials Only
All of our trials are run by licensed doctors, researchers, and healthcare companies.