Aspirin for Preeclampsia

This trial explores how aspirin affects blood cells in pregnant individuals at risk of developing preeclampsia, a condition that can cause high blood pressure during pregnancy. Participants will take a small dose of aspirin twice daily for four weeks. Researchers will then analyze blood samples to understand aspirin's effects during pregnancy. Pregnant individuals less than 17 weeks along and receiving prenatal care at NYU Langone may be suitable candidates, especially if there is a risk of developing preeclampsia. As an Early Phase 1 trial, this research aims to understand aspirin's effects in pregnant individuals, offering participants a chance to contribute to groundbreaking insights.

The trial does not specify if you need to stop taking your current medications, but you cannot participate if you are on antithrombotic or antiplatelet therapy.

Research has shown that low-dose aspirin is generally safe for pregnant women at risk of preeclampsia. Studies have found that it can lower the risk of developing preeclampsia without major safety concerns. One large study found no significant increase in bleeding problems with daily doses of 150 to 160 mg. Another review of several studies reported a 17% reduction in preeclampsia with low-dose aspirin use.

Unlike the standard treatments for preeclampsia, which typically involve managing symptoms with medications like antihypertensives and corticosteroids, aspirin is being explored for its potential preventative properties. Aspirin is unique because it targets the underlying inflammation and blood clotting issues associated with preeclampsia, potentially reducing the risk of complications. Researchers are excited about this treatment because it offers a simple, widely available option that could be integrated easily into existing care protocols, potentially benefiting a large number of patients with minimal side effects.

Research has shown that low-dose aspirin can lower the risk of preeclampsia, a serious condition during pregnancy. A review of 59 studies found that low-dose aspirin reduced the risk of preeclampsia by 17%. Taking aspirin doses of 75 mg or more, starting early in pregnancy and continuing regularly, proves effective, especially if begun before 16 weeks. Some studies suggest that doses over 100 mg may further reduce the risk of early preeclampsia. In this trial, participants will take 81 mg of aspirin twice daily (162 mg total) for 4 weeks. Overall, aspirin is considered helpful for preventing preeclampsia in pregnant women at risk.²³⁶⁷⁸