Antiseptics for Dental Implant Success

This trial tests whether two antiseptic gels, hydrogen peroxide and chlorhexidine, can prevent dental implant failure by reducing harmful oral bacteria. It specifically examines if these treatments can improve implant success rates and reduce the need for additional surgeries. The trial suits active duty military members with at least six months remaining at their current duty station, who do not use tobacco and do not have certain health conditions affecting healing. As an Early Phase 1 trial, this research aims to understand how these treatments work in people, offering participants a chance to contribute to groundbreaking dental health advancements.

The trial excludes participants who are on medications that affect soft tissue or bone healing, so you may need to stop taking such medications to participate.

Research has shown that chlorhexidine is generally safe for dental use. One study found no harmful effects when used to prevent mouth infections in high-risk patients, suggesting it is well-tolerated for dental implant procedures.

For hydrogen peroxide, research indicates it can effectively clean dental implants. One study found that hydrogen peroxide disinfects implants as well as, or better than, chlorhexidine. However, detailed safety information for hydrogen peroxide is limited. Another study on hydrogen peroxide mouthwash showed it to be safe, but this was for a different purpose.

Researchers are excited about using antiseptics like Chlorhexidine and Hydrogen Peroxide for dental implant success because they offer potential benefits beyond the standard of care, which typically involves basic oral hygiene practices. Chlorhexidine is known for its strong antibacterial properties, helping to reduce the risk of infection after implant surgery. Hydrogen Peroxide, on the other hand, not only kills bacteria but also has a bubbling action that can help clean and remove debris around the implant site. These unique features could potentially improve healing and implant success rates, providing a promising complement to existing dental care routines.

Research has shown that chlorhexidine, which participants in this trial may receive, helps manage infections around dental implants by reducing bacteria and swelling. This leads to fewer problems with the gums and bone around the implant, potentially improving implant success. Another treatment option in this trial is hydrogen peroxide, which has demonstrated equal or even better results in cleaning dental implants compared to chlorhexidine, especially when combined with a laser. Both treatments aim to clean the implant area to prevent harmful bacteria from causing issues. These findings suggest that using either chlorhexidine or hydrogen peroxide could improve dental implant success rates by maintaining a cleaner and healthier area.¹²⁴⁶⁷