Panitumumab-IRDye800 for Brain Cancer
What You Need to Know Before You Apply
What is the purpose of this trial?
This pilot clinical study evaluates the safety and imaging performance of panitumumab-IRDye800 (pan800), a fluorescent, EGFR-targeted imaging agent - in patients undergoing neurosurgical resection of intracranial lesions.
Who Is on the Research Team?
Peter Morone, MD
Principal Investigator
Vanderbilt University Medical Center
Are You a Good Fit for This Trial?
This trial is for adults (18+) with brain tumors or lesions who are scheduled for surgical removal. Participants must have normal blood tests, not be pregnant if female, and be able to give consent themselves or through a healthcare decision maker.Inclusion Criteria
Exclusion Criteria
What Are the Treatments Tested in This Trial?
Interventions
- Panitumumab-IRDye800
Trial Overview
The study is testing Panitumumab-IRDye800, a fluorescent imaging agent that targets EGFR, to see how well it helps surgeons detect brain tumors during surgery. The main focus is on safety and how clearly the dye highlights tumor tissue.
How Is the Trial Designed?
2
Treatment groups
Experimental Treatment
Participants will receive a single 50 mg IV dose of panitumumab-IRDye800 (pan800) 1-5 days before standard-of-care neurosurgical resection. Participants will undergo immediate post-infusion monitoring, postoperative pharmacokinetic blood draws, and adverse-event assessments through surgery and a Day 15 (±7) follow-up.
Participants will receive a single 100 mg IV dose of panitumumab-IRDye800 (pan800) 1-5 days before their standard-of-care neurosurgical resection. Participants will undergo immediate post-infusion monitoring along with postoperative pharmacokinetic and immunogenicity blood sampling and adverse-event assessments through surgery and the Day 15 (±7) follow-up visit.
Find a Clinic Near You
Who Is Running the Clinical Trial?
Eben Rosenthal
Lead Sponsor
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