Ivabradine for Heart Rate Reduction in Healthy Adults
What You Need to Know Before You Apply
What is the purpose of this trial?
During exercise, working muscles require more oxygen. The heart meets this demand in two ways: by beating faster (heart rate) and by pumping more blood with each beat (stroke volume). Heart rate increases steadily with exercise intensity until exhaustion, but the amount of blood pumped with each beat tends to plateau at moderate intensities. Why the amount of blood pumped with each beat becomes limited before heart rate, however, is not well understood.
Studying these mechanisms is difficult because most drugs that lower heart rate also affect how strongly the heart pumps, making it hard to separate the two effects. One medication that can help with this is ivabradine, which is used to treat people with heart disease who have high resting heart rates. It slows the heart rate without changing how strongly the heart pumps.
This study will investigate whether ivabradine lowers heart rate during exercise in healthy younger and older adults, and whether a higher dose lowers heart rate more. The results will help us better understand how heart rate influences the heart's ability to supply oxygen to the body during exercise, and what limits the ability to exercise as people age.
Participants will:
* Attend three visits at SportsCardiologyBC in Vancouver
* Complete a cycling exercise test at each visit to measure heart rate and how hard they can exercise
* Take ivabradine (a heart-rate-lowering medication) before the exercise test at Visits 2 and 3 (a lower dose at Visit 2 and a higher dose at Visit 3)
* Be monitored for side effects including slow heart rate, visual symptoms, and headache.
Are You a Good Fit for This Trial?
This trial is for healthy adults aged 19-39 or 60-79 who exercise at least once a week. People with heart, lung, liver, kidney disease, high or low blood pressure, abnormal heart rhythms, certain medication use, lactose intolerance, recent smoking/vaping, pregnancy/breastfeeding cannot join.Inclusion Criteria
Exclusion Criteria
Timeline for a Trial Participant
Screening
Participants are screened for eligibility to participate in the trial
Treatment
Participants receive two single oral doses of ivabradine at separate visits, with continuous monitoring and exercise tests
Follow-up
Participants are monitored for safety and effectiveness after treatment
What Are the Treatments Tested in This Trial?
Interventions
- Ivabradine
Trial Overview
The study tests if ivabradine (a medicine that lowers heart rate) can safely reduce heart rate during exercise in healthy younger and older adults. Participants take two different doses of ivabradine before cycling tests to see how it affects their exercise performance.
How Is the Trial Designed?
1
Treatment groups
Experimental Treatment
All participants receive two single oral doses of ivabradine in a fixed sequence across separate experimental visits.
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Who Is Running the Clinical Trial?
University of British Columbia
Lead Sponsor
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