L-Theanine for Cancer

Not yet recruiting at 3 trial locations
No Placebo GroupAll trial participants will receive the active study treatment (no placebo)

What You Need to Know Before You Apply

What is the purpose of this trial?

This trial explores how L-theanine, a compound in green tea, can help cancer patients feel more relaxed and improve their mood after treatment. Researchers aim to determine the best dose and assess its effectiveness in reducing stress and enhancing mental well-being. Participants will take L-theanine once or twice daily for six weeks. Those who have been cancer-free and under medical surveillance for at least six months and often feel anxious might find this trial suitable. As an Early Phase 1 trial, this research focuses on understanding how L-theanine works in people, offering participants the chance to be among the first to benefit from this treatment.

Do I need to stop taking my current medications to join the trial?

The trial does not specify that you need to stop taking your current medications, but you must not have changed your psychiatric medications in the past 60 days. You also cannot use other alternative medicines, herbs, or high-dose vitamins unless correcting a deficiency.

Is there any evidence suggesting that L-theanine is likely to be safe for humans?

Research shows that L-theanine, a natural substance in green tea, is generally safe. Studies have found that L-theanine neither causes cancer nor affects reproduction. People have consumed it in tea for a long time without known safety issues. Further research suggests it can reduce stress and improve mood without serious side effects. Although this trial is in the early stages, existing evidence supports the safety of L-theanine in humans.12345

Why are researchers excited about this trial's treatment?

Researchers are excited about L-Theanine as a cancer treatment because it offers a unique approach compared to traditional therapies like chemotherapy and radiation. L-Theanine is derived from tea leaves and is known for its calming properties, but its potential in cancer treatment lies in its ability to enhance the effectiveness of existing treatments while potentially reducing side effects. Unlike conventional treatments that often come with a host of severe side effects, L-Theanine's natural origin might offer a more gentle alternative. Additionally, it can be administered orally, making it an accessible option for patients seeking less invasive treatment methods.

What evidence suggests that L-theanine might be an effective treatment for cancer patients' relaxation and mood?

Research has shown that L-theanine, a substance in green tea leaves, may help cancer patients feel more relaxed and improve their mood. L-theanine increases certain chemicals in the body that reduce stress and stabilize mood. Early studies suggest it can positively impact mental health and well-being. In lab tests, L-theanine also slowed the spread of cancer cells, particularly in prostate cancer. Although more research is needed, these early findings offer hope for its use in supporting the mental health of cancer patients. Participants in this trial will receive L-theanine either once or twice daily to evaluate its effects.23567

Who Is on the Research Team?

EV

Erica Veguilla

Principal Investigator

City of Hope Medical Center

Are You a Good Fit for This Trial?

This trial is for cancer patients who are currently under surveillance, meaning they're being closely monitored but not actively receiving treatment. The study aims to see if L-theanine can help improve their relaxation and mood.

Inclusion Criteria

Documented informed consent of the participant and/or legally authorized representative
I am willing to follow all study requirements, including taking L-theanine.
Participants must not have used any herbs or supplements in the past 30 days
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Exclusion Criteria

Any patients currently enrolled in other clinical trials that might interfere with the results of this study
History of allergic reactions attributed to compounds of similar chemical or biologic composition to study agent
Any patients with an ongoing active/unstable psychiatric condition, depressive/bi-polar related disorders, anxiety, psychosis disorders, or substance use that may interfere with the ability to participate in the study as outlined in the study procedures section of the protocol
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Timeline for a Trial Participant

Screening

Participants are screened for eligibility to participate in the trial

2-4 weeks

Treatment

Participants receive L-theanine orally once daily or twice daily for 6 weeks

6 weeks

Follow-up

Participants are monitored for safety and effectiveness after treatment

2 weeks

What Are the Treatments Tested in This Trial?

Interventions

  • L-Theanine
Trial Overview The trial is testing the use of L-theanine, a compound from green tea leaves, to determine the best dosage and its effectiveness in enhancing mental health by potentially reducing stress and stabilizing mood among these patients.
How Is the Trial Designed?
2Treatment groups
Experimental Treatment
Group I: Arm II (L-theanine BID)Experimental Treatment2 Interventions
Group II: Arm I (L-theanine QD)Experimental Treatment2 Interventions

Find a Clinic Near You

Who Is Running the Clinical Trial?

City of Hope Medical Center

Lead Sponsor

Trials
614
Recruited
1,924,000+

National Cancer Institute (NCI)

Collaborator

Trials
14,080
Recruited
41,180,000+

Citations

1.pubmed.ncbi.nlm.nih.govpubmed.ncbi.nlm.nih.gov/33891786/
Theanine and cancer: A systematic review of the literatureMost of the included in vitro and ex vivo studies reported beneficial effects of theanine on the proliferation, apoptosis, metastasis, migration, and invasion ...
L-theanine suppresses the metastasis of prostate cancer ...Here, we found that L-theanine could suppress invasion, migration, and increase cell-cell adhesion of prostate cancer cells in vitro and in vivo.
L-Theanine to Support Relaxation and Mood for Cancer ...This clinical trial tests the feasibility, best dose, and effectiveness of L-theanine for supporting relaxation and mood among cancer ...
L-TheanineThis increase in glutamate likely results in increased efflux of doxorubicin from the cells, thereby decreasing toxicity. Animal models suggest ...
Theanine, an antitumor promoter, induces apoptosis of ...These data indicated that glutamine prevented theanine-induced cancer cell death. Theanine induces HepG2 cell apoptosis under acute glutamine ...
Safety Data SheetChemicals known to cause cancer: Substance is not listed. · Chemicals known to cause reproductive toxicity for females: Substance is not listed.
L-Theanine | C7H14N2O3 | CID 439378 - PubChemOverall, it was demonstrated that theanine is a safe compound and its repeated oral administration reduces oxidation levels in the brain, especially the Cx, by ...
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