Tranexamic Acid for Reducing Blood Loss During Surgery for Pelvic Mass

This trial explores how well tranexamic acid reduces blood loss in patients with pelvic tumors undergoing hemipelvectomy surgery. Tranexamic acid stabilizes blood clots during surgery. The trial includes two groups: one receives tranexamic acid during surgery, while the other undergoes standard surgery without it. Patients with a pelvic tumor scheduled for surgery at the University of Texas MD Anderson Cancer Center may qualify for this trial. As an Early Phase 1 trial, this research aims to understand how tranexamic acid works in people, offering participants the chance to contribute to groundbreaking medical knowledge.

The trial information does not specify whether you need to stop taking your current medications. It's best to discuss this with the trial coordinators or your doctor.

Research has shown that tranexamic acid is generally safe for use during surgeries. Studies have found it can reduce blood loss without increasing the risk of complications. For example, research on patients with pelvic fractures showed that tranexamic acid reduced the need for blood transfusions, indicating it is well-tolerated. Another study confirmed that administering tranexamic acid through an IV can decrease blood loss and the need for transfusions without adding extra risks during surgery. These findings suggest that tranexamic acid is a safe option for reducing blood loss in surgical settings.¹²³⁴⁵

Researchers are excited about using tranexamic acid during surgery for pelvic mass removal because it offers a promising way to reduce blood loss. Unlike standard surgical practices that don't incorporate this medication, tranexamic acid works by preventing blood clots from breaking down too quickly, which can help minimize bleeding. Administered intravenously just before and during surgery, this approach could improve surgical outcomes and potentially lead to faster recovery times.

Research has shown that tranexamic acid reduces blood loss during surgeries. It proves effective in procedures like pelvic fractures and abdominal hysterectomies by helping blood clots remain intact. In patients with pelvic or hip socket fractures, tranexamic acid led to fewer blood transfusions. The CRASH-2 trial found that tranexamic acid lowered the risk of death from bleeding. In this trial, one group of participants will receive tranexamic acid to evaluate its effectiveness in reducing blood loss during complex surgeries like hemipelvectomy. These findings suggest that tranexamic acid could be useful in this context.¹²⁴⁶⁷