New MRI Methods for Heart Failure

This trial tests new MRI methods to better understand and diagnose heart failure with preserved ejection fraction (HFpEF), where the heart muscle contracts normally but struggles to relax. Researchers compare MRI to other imaging techniques to evaluate their effectiveness in detecting changes in the heart's small blood vessels and tissue. Participants may receive medications like Adenosine and Regadenoson to enhance blood flow visibility during imaging. Ideal participants include those with a confirmed HFpEF diagnosis who are comfortable undergoing MRI scans. As an Early Phase 1 trial, this research aims to understand how these new MRI methods work in people, offering participants the chance to contribute to groundbreaking advancements in heart failure diagnosis.

Previous studies have shown that both adenosine and regadenoson are safe for use in heart imaging. Adenosine is generally well-tolerated, with serious side effects occurring in less than 1% of patients. Doctors use it in stress tests to assess heart function, and most people, even those with severe heart conditions, handle it well.

Regadenoson, another drug for heart imaging, is also considered safe and well-tolerated. Side effects are usually mild and resolve on their own. Common ones include nausea, shortness of breath, and headaches, though these are infrequent.

Researchers are excited about these new imaging methods because they offer a fresh way to understand heart failure with preserved ejection fraction (HFpEF), a complex condition with limited treatment options. Unlike traditional imaging methods, which often rely on standard MRI or CT scans, this approach uses adenosine and regadenoson alongside O-15 labeled radioactive water for enhanced MRI and PET imaging. This could lead to more precise diagnosis and monitoring by highlighting the heart's blood flow and function in ways that current techniques can't, potentially paving the way for better-targeted therapies in the future.

This trial will compare the effects of adenosine and regadenoson in cardiac imaging. Research has shown that both adenosine and regadenoson improve blood flow to the heart. Adenosine widens the heart's arteries, boosting blood flow and enhancing heart function. It also manages irregular heartbeats. Regadenoson, a potent stress agent, expands the heart's blood vessels to assess blood flow, aiding in the detection of coronary artery disease. This can provide insights into heart issues such as heart failure. Both treatments help doctors evaluate heart function and better understand heart conditions.⁶⁷⁸⁹¹⁰