Olfactory Training for HIV

(BOOST Trial)

This trial explores two smell-related treatments to determine if they can improve the sense of smell and cognitive skills in adults living with HIV. One group will practice smelling specific scents twice a day (Olfactory Training at Home), while the other will use a scent diffuser at night for eight weeks (Overnight Diffuser Group). The study also aims to assess the practicality and acceptability of these treatments. Adults with HIV who experience memory or thinking challenges might be suitable candidates for this trial. As an Early Phase 1 trial, this research focuses on understanding how these treatments work in people, offering participants the chance to be among the first to explore innovative approaches to enhance cognitive function.

The trial information does not specify whether you need to stop taking your current medications. It's best to discuss this with the trial coordinators.

Research has shown that olfactory training is generally safe for improving the sense of smell. Previous studies found it beneficial for individuals with and without smell loss. Most participants experience positive results without major issues. Some may encounter mild side effects like headaches or a stuffy nose, but these are uncommon.

For those using the overnight diffuser, essential oils are involved. They have shown potential benefits in some health areas, but their safety can vary. Essential oils are very concentrated, and inhaling them might irritate the nose or throat, causing coughing or discomfort. Some oils can even be harmful if not used properly.

Researchers are excited about the olfactory training for HIV because it offers a novel, non-invasive approach to addressing sensory impairments often experienced by individuals with HIV. Unlike conventional treatments that focus primarily on managing viral load and immune function with antiretroviral therapy, this approach aims to enhance quality of life by potentially improving the sense of smell. The treatments use a unique delivery method—either a standard smell training kit or an overnight diffuser with essential oils—making it an accessible option for home use and allowing participants to engage with their therapy creatively and personally. This innovative strategy could open new avenues for sensory therapy in HIV care.

This trial will compare two approaches to olfactory training for individuals with HIV. Studies have shown that regularly smelling specific scents, known as olfactory training, can help improve the sense of smell in those who have lost it. Participants in the Standard Smell Training Group will use a standard smell training kit with basic odorants. Meanwhile, those in the Overnight Diffuser Group will use essential oils, which have demonstrated antiviral properties and might help with symptoms of viral infections, including HIV. Although more research is needed, essential oils have been used in medical settings to relieve symptoms. Both approaches aim to improve the sense of smell and may also benefit brain function.²³⁶⁷⁸