NR Supplementation for Bone Marrow Transplant Engraftment Improvement
What You Need to Know Before You Apply
What is the purpose of this trial?
This trial seeks a safe method to enhance recovery after a bone marrow transplant. Researchers are testing whether adding nicotinamide riboside, a vitamin B supplement, to donor cells can increase blood stem cell numbers and accelerate recovery. The trial seeks participants planning to undergo a specific type of bone marrow transplant with a matching human donor. Individuals with certain allergies or conditions that might interfere with the trial requirements are not suitable for this study. As an Early Phase 1 trial, this research aims to understand how the treatment works in people, offering participants the chance to contribute to groundbreaking medical advancements.
Do I need to stop my current medications for the trial?
The trial information does not specify whether you need to stop taking your current medications. It's best to discuss this with the trial coordinators or your doctor.
Is there any evidence suggesting that nicotinamide riboside is likely to be safe for humans?
Research has shown that nicotinamide riboside (NR), a type of vitamin B3, is generally safe. Some studies indicate that NR is as safe as nicotinamide, another form of vitamin B3. Even in high amounts, the main concerns involve effects on the liver and kidneys, but these effects were not serious.
NR is also sold as a dietary supplement, suggesting it is safe for most people. However, this study is in an early stage, so researchers are still carefully monitoring its safety. While NR appears promising, participants should know it is still under testing, and any potential risks are being closely observed.12345Why do researchers think this study treatment might be promising?
Researchers are excited about Nicotinamide Riboside (NR) because it offers a fresh approach to improving bone marrow transplant engraftment. Unlike traditional treatments that focus on immune suppression or support, NR works by boosting cellular energy and enhancing cell repair through a unique mechanism that increases NAD+ levels, a vital molecule for cell function and resilience. This could potentially lead to faster and more effective engraftment, providing a significant advantage over existing therapies.
What evidence suggests that nicotinamide riboside might be an effective treatment for improving engraftment?
Research suggests that nicotinamide riboside (NR), a type of vitamin B3, might enhance the success of bone marrow transplants. In this trial, participants will receive NR to evaluate its effects on transplant outcomes. Studies have found that NR can increase the number of blood stem cells, potentially speeding up the time for new cells to grow in the body after a transplant. This could reduce the risk of complications and lead to better long-term health. Specifically, NR has increased the number of early-stage cells without exhausting them, significantly improving survival rates. Overall, NR shows promise in supporting healthier cell growth and recovery after a bone marrow transplant.46789
Who Is on the Research Team?
Ronald Sobecks, MD
Principal Investigator
Cleveland Clinic, Case Comprehensive Cancer Center
Are You a Good Fit for This Trial?
This trial is for individuals who are eligible for a bone marrow transplant with myeloablative conditioning and have an HLA-identical donor. It's not suitable for pregnant or breastfeeding women, those with uncontrolled illnesses or psychiatric conditions that could affect compliance, or anyone allergic to NR compounds like niacin.Inclusion Criteria
Exclusion Criteria
Timeline for a Trial Participant
Screening
Participants are screened for eligibility to participate in the trial
Treatment
Participants receive nicotinamide riboside supplementation to improve engraftment after allogeneic hematopoietic cell transplantation
Engraftment Monitoring
Participants are monitored for engraftment, defined as the process during which transplanted stem cells begin to grow in the bone marrow
Follow-up
Participants are monitored for safety and effectiveness after treatment, including neutrophil and platelet recovery
What Are the Treatments Tested in This Trial?
Interventions
- Nicotinamide Riboside (NR)
Find a Clinic Near You
Who Is Running the Clinical Trial?
Case Comprehensive Cancer Center
Lead Sponsor