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CB-CT Imaging for Stroke

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Overseen ByRadiology Studies
Age: 18+
Sex: Any
Trial Phase: Academic
Sponsor: University of Wisconsin, Madison
No Placebo GroupAll trial participants will receive the active study treatment (no placebo)

What You Need to Know Before You Apply

What is the purpose of this trial?

This trial tests a new imaging method for treating stroke patients. It aims to determine if cone beam computed tomography (CB-CT) can accelerate both the imaging and treatment process for acute ischemic stroke, which occurs when a major artery in the brain becomes blocked. Participants will receive an evaluation with either the experimental CB-CT or the standard multi-detector CT (MD-CT). Individuals who have recently experienced a stroke and have a major artery blockage might be suitable for this study. As an unphased trial, this study allows participants to contribute to innovative research that could enhance stroke treatment.

Do I need to stop my current medications for the trial?

The trial information does not specify whether you need to stop taking your current medications. It's best to discuss this with the trial coordinators or your doctor.

What prior data suggests that CB-CT imaging is safe for stroke patients?

Research has shown that C-arm Cone Beam CT (CBCT) is generally easy for patients to handle. Studies on this imaging technology have found that it reduces image distortions, making scans clearer and more reliable. This clarity likely ensures safety for brain imaging, as clearer images help doctors make better decisions without additional risk.

No reports have linked serious problems to using C-arm CBCT for procedures involving blood vessels in the brain. The technology is designed to make image-taking faster and better, potentially reducing time and stress for patients during procedures.

While this study doesn't provide detailed safety data, existing research supports the idea that this imaging method is safe in medical settings.12345

Why are researchers excited about this trial?

Researchers are excited about the C-arm Cone Beam CT (CBCT) imaging technique for stroke because it offers a more rapid and detailed visualization of blood flow in the brain compared to traditional methods. Unlike conventional multi-detector CT (MD-CT) scans, which are part of the standard treatment for assessing strokes, the C-arm CBCT uses SMART RECON software to provide a time-resolved CT angiogram and CT perfusion. This can potentially speed up diagnosis and lead to faster, more precise interventions, which is crucial in stroke management where time is of the essence.

What evidence suggests that CB-CT imaging is effective for stroke?

Research has shown that C-arm Cone Beam CT (CBCT), which participants in this trial may receive, could greatly enhance stroke treatment. Studies have found that CBCT provides fast and accurate images, essential for rapid stroke intervention. It uses a special type of CT scan to deliver detailed pictures of blood flow in the brain, aiding doctors in making swift decisions. Recent improvements have clarified the images, increasing trust in its use for diagnosing strokes. This method could significantly reduce the time needed to start treatment, crucial for better recovery in stroke patients.12367

Who Is on the Research Team?

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Beverly Aagaard-Kienitz, MD

Principal Investigator

University of Wisconsin, Madison

Are You a Good Fit for This Trial?

This trial is for adults over 18 with a recent ischemic stroke within the last 24 hours, who have a blockage in a large artery and are not severely ill with other conditions. They must have an NIHSS score of less than 8, indicating mild to moderate stroke severity, and cannot be pregnant or have severe kidney disease.

Inclusion Criteria

No severe co-morbidities
Patients of childbearing potential must not be pregnant
Your National Institutes of Health Stroke Scale (NIHSS) score is less than 8.
See 2 more

Exclusion Criteria

Patients that are pregnant
You have had a kidney transplant in the past.
You have a history of serious kidney disease (e.g. stage 4-5).

Timeline for a Trial Participant

Screening

Participants are screened for eligibility to participate in the trial

1-2 weeks

Treatment

Participants undergo either C-arm CBCT or MD-CT imaging for the assessment of acute ischemic stroke

1 visit (up to 120 minutes)

Follow-up

Participants are monitored for safety and effectiveness after imaging procedures

4 weeks

What Are the Treatments Tested in This Trial?

Interventions

  • C-arm Cone Beam CTP Guided Cerebrovascular Interventions
Trial Overview The study is testing if using C-arm Cone Beam Computed Tomography (CB-CT) can save substantial time during cerebrovascular interventions by quickly acquiring and reconstructing images for acute ischemic stroke patients compared to standard Multi-detector CT.
How Is the Trial Designed?
2Treatment groups
Experimental Treatment
Active Control
Group I: C-ARM CBCTExperimental Treatment1 Intervention
Group II: MD-CTActive Control1 Intervention

Find a Clinic Near You

Who Is Running the Clinical Trial?

University of Wisconsin, Madison

Lead Sponsor

Trials
1,249
Recruited
3,255,000+

National Institute for Biomedical Imaging and Bioengineering (NIBIB)

Collaborator

Trials
102
Recruited
21,600+

Citations

Optimized C-arm Cone Beam CT for the Endovascular ...The main objective is to assess the diagnostic confidence of this optimized C-arm Cone Beam CT, named in french ASO, in the NAS for the detection of brain ...
Clinical Applications of Conebeam CTP Imaging in ...Our aim was to provide an overview of conebeam CT techniques for quantifying cerebral perfusion, their clinical applications, and validation.
Acquisition Protocol CBCT in Acute Stroke Intervention ...This study is to evaluate the effectiveness of CBCT as additional imaging in acute stroke intervention.
C-arm Cone Beam CT Perfusion Guided Cerebrovascular ...This is an evaluation to determine the efficacy of the use of C-arm CBCT with SMART RECON novel software for the rapid assessment of time- ...
improving brain cone-beam CT image artifacts for stroke ...Conclusions Recent developments in CBCT imaging protocols have significantly improved image artifacts, which has improved diagnostic confidence for stroke and ...
Three-dimensional C-arm Cone-beam CT - JVIRIt may be that future studies will show that the use of C-arm cone-beam CT improves the safety of spine interventions. ... Angiographic CT in cerebrovascular ...
Optimized C-arm Cone Beam CT for the Endovascular ...To compare the effectiveness and safety of ASO diagnostic, the variability of the diagnostic accuracy concerning the staging of the stroke, the ...
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