Vitamin K1

Jaundice, Obstructive, long-acting anticoagulant rodenticides, Vitamin K Deficiency + 17 more

Treatment

10 FDA approvals

20 Active Studies for Vitamin K1

What is Vitamin K1

Phylloquinone

The Generic name of this drug

Treatment Summary

Vitamin K1, also known as phylloquinone or phytonadione, is a type of fat-soluble vitamin used since 1939. It helps the body form blood clotting factors and is used to treat coagulation disorders caused by a vitamin K deficiency. Vitamin K1 has been approved by the FDA since 1955.

Mephyton

is the brand name

image of different drug pills on a surface

Vitamin K1 Overview & Background

Brand Name

Generic Name

First FDA Approval

How many FDA approvals?

Mephyton

Phylloquinone

1955

65

Approved as Treatment by the FDA

Phylloquinone, also known as Mephyton, is approved by the FDA for 10 uses including Jaundice, Obstructive and Hypoprothrombinemia .

Jaundice, Obstructive

Used to treat Jaundice, Obstructive in combination with Taurocholic acid

Hypoprothrombinemia

Fistula, Biliary

Used to treat Fistula, Biliary in combination with Taurocholic acid

antibacterial therapy

Biliary Fistula

Used to treat Fistula, Biliary in combination with Taurocholic acid

hemorrhagic disease of the newborn

Hypoprothrombinemias

Jaundice, Obstructive

Used to treat Jaundice, Obstructive in combination with Taurocholic acid

Hemorrhagic Disease of Newborn

Salicylate

Effectiveness

How Vitamin K1 Affects Patients

Phylloquinone is a type of vitamin K that can help treat blood clotting issues caused by a vitamin K deficiency. It stays in the body for a long time, so it only needs to be taken occasionally. Most people can tolerate large doses of this vitamin, but it's important to monitor prothrombin time while taking it and be aware of the risk of allergic reactions when given through a needle.

How Vitamin K1 works in the body

Vitamin K helps the body form blood clots. It does this by attaching carboxylic acid groups to a molecule called glutamate, which helps clotting factors bind to calcium. These clotting factors are released from the liver, restoring normal clotting. Vitamin K may also help protect joints from calcification, increase type two collagen and help with bone density. Researchers are still investigating its effects on arthritis, bone density and artery calcification.

When to interrupt dosage

The dose of Vitamin K1 is contingent upon the diagnosed condition, including Sprue, Vitamin supplementation and Ulcerative Colitis. The magnitude of dosage is subject to the application method itemized in the table below.

Condition

Dosage

Administration

long-acting anticoagulant rodenticides

, 5.0 mg, 10.0 mg/mL, 2.0 mg/mL, 1.0 mg, 0.2 mg/mL, 0.015 mg/mL, 0.15 mg/mL, 0.2 mg, 0.02 mg, 0.08 mg, 0.15 mg, 0.02 mg/mL, 0.1 mg/mL

, Tablet, Oral, Tablet - Oral, Injection, emulsion - Parenteral, Injection, emulsion, Parenteral, Intramuscular; Parenteral; Subcutaneous, Intramuscular; Intravenous; Subcutaneous, Injection, emulsion - Intramuscular; Intravenous; Subcutaneous, Solution, Emulsion - Intramuscular; Intravenous; Subcutaneous, Emulsion, Liquid - Intramuscular, Intramuscular, Injection, powder, lyophilized, for solution - Intravenous, Injection, solution - Intravenous, Capsule, Capsule - Oral, Solution - Parenteral, Intravenous, Injection, powder, lyophilized, for solution, Injection, solution, Injection, emulsion - Intramuscular; Parenteral; Subcutaneous, Liquid, Liquid - Intravenous, Kit, Kit - Oral, Injection - Intravenous, Injection, Solution / drops, Solution - Intramuscular; Intravenous; Subcutaneous, Solution / drops - Oral, Injection, solution - Intramuscular; Intravenous; Subcutaneous

Vitamin supplementation therapy

, 5.0 mg, 10.0 mg/mL, 2.0 mg/mL, 1.0 mg, 0.2 mg/mL, 0.015 mg/mL, 0.15 mg/mL, 0.2 mg, 0.02 mg, 0.08 mg, 0.15 mg, 0.02 mg/mL, 0.1 mg/mL

, Tablet, Oral, Tablet - Oral, Injection, emulsion - Parenteral, Injection, emulsion, Parenteral, Intramuscular; Parenteral; Subcutaneous, Intramuscular; Intravenous; Subcutaneous, Injection, emulsion - Intramuscular; Intravenous; Subcutaneous, Solution, Emulsion - Intramuscular; Intravenous; Subcutaneous, Emulsion, Liquid - Intramuscular, Intramuscular, Injection, powder, lyophilized, for solution - Intravenous, Injection, solution - Intravenous, Capsule, Capsule - Oral, Solution - Parenteral, Intravenous, Injection, powder, lyophilized, for solution, Injection, solution, Injection, emulsion - Intramuscular; Parenteral; Subcutaneous, Liquid, Liquid - Intravenous, Kit, Kit - Oral, Injection - Intravenous, Injection, Solution / drops, Solution - Intramuscular; Intravenous; Subcutaneous, Solution / drops - Oral, Injection, solution - Intramuscular; Intravenous; Subcutaneous

Ulcerative Colitis

, 5.0 mg, 10.0 mg/mL, 2.0 mg/mL, 1.0 mg, 0.2 mg/mL, 0.015 mg/mL, 0.15 mg/mL, 0.2 mg, 0.02 mg, 0.08 mg, 0.15 mg, 0.02 mg/mL, 0.1 mg/mL

, Tablet, Oral, Tablet - Oral, Injection, emulsion - Parenteral, Injection, emulsion, Parenteral, Intramuscular; Parenteral; Subcutaneous, Intramuscular; Intravenous; Subcutaneous, Injection, emulsion - Intramuscular; Intravenous; Subcutaneous, Solution, Emulsion - Intramuscular; Intravenous; Subcutaneous, Emulsion, Liquid - Intramuscular, Intramuscular, Injection, powder, lyophilized, for solution - Intravenous, Injection, solution - Intravenous, Capsule, Capsule - Oral, Solution - Parenteral, Intravenous, Injection, powder, lyophilized, for solution, Injection, solution, Injection, emulsion - Intramuscular; Parenteral; Subcutaneous, Liquid, Liquid - Intravenous, Kit, Kit - Oral, Injection - Intravenous, Injection, Solution / drops, Solution - Intramuscular; Intravenous; Subcutaneous, Solution / drops - Oral, Injection, solution - Intramuscular; Intravenous; Subcutaneous

Biliary Fistula

, 5.0 mg, 10.0 mg/mL, 2.0 mg/mL, 1.0 mg, 0.2 mg/mL, 0.015 mg/mL, 0.15 mg/mL, 0.2 mg, 0.02 mg, 0.08 mg, 0.15 mg, 0.02 mg/mL, 0.1 mg/mL

, Tablet, Oral, Tablet - Oral, Injection, emulsion - Parenteral, Injection, emulsion, Parenteral, Intramuscular; Parenteral; Subcutaneous, Intramuscular; Intravenous; Subcutaneous, Injection, emulsion - Intramuscular; Intravenous; Subcutaneous, Solution, Emulsion - Intramuscular; Intravenous; Subcutaneous, Emulsion, Liquid - Intramuscular, Intramuscular, Injection, powder, lyophilized, for solution - Intravenous, Injection, solution - Intravenous, Capsule, Capsule - Oral, Solution - Parenteral, Intravenous, Injection, powder, lyophilized, for solution, Injection, solution, Injection, emulsion - Intramuscular; Parenteral; Subcutaneous, Liquid, Liquid - Intravenous, Kit, Kit - Oral, Injection - Intravenous, Injection, Solution / drops, Solution - Intramuscular; Intravenous; Subcutaneous, Solution / drops - Oral, Injection, solution - Intramuscular; Intravenous; Subcutaneous

hemorrhagic disease of the newborn

, 5.0 mg, 10.0 mg/mL, 2.0 mg/mL, 1.0 mg, 0.2 mg/mL, 0.015 mg/mL, 0.15 mg/mL, 0.2 mg, 0.02 mg, 0.08 mg, 0.15 mg, 0.02 mg/mL, 0.1 mg/mL

, Tablet, Oral, Tablet - Oral, Injection, emulsion - Parenteral, Injection, emulsion, Parenteral, Intramuscular; Parenteral; Subcutaneous, Intramuscular; Intravenous; Subcutaneous, Injection, emulsion - Intramuscular; Intravenous; Subcutaneous, Solution, Emulsion - Intramuscular; Intravenous; Subcutaneous, Emulsion, Liquid - Intramuscular, Intramuscular, Injection, powder, lyophilized, for solution - Intravenous, Injection, solution - Intravenous, Capsule, Capsule - Oral, Solution - Parenteral, Intravenous, Injection, powder, lyophilized, for solution, Injection, solution, Injection, emulsion - Intramuscular; Parenteral; Subcutaneous, Liquid, Liquid - Intravenous, Kit, Kit - Oral, Injection - Intravenous, Injection, Solution / drops, Solution - Intramuscular; Intravenous; Subcutaneous, Solution / drops - Oral, Injection, solution - Intramuscular; Intravenous; Subcutaneous

Anticoagulant Therapy

, 5.0 mg, 10.0 mg/mL, 2.0 mg/mL, 1.0 mg, 0.2 mg/mL, 0.015 mg/mL, 0.15 mg/mL, 0.2 mg, 0.02 mg, 0.08 mg, 0.15 mg, 0.02 mg/mL, 0.1 mg/mL

, Tablet, Oral, Tablet - Oral, Injection, emulsion - Parenteral, Injection, emulsion, Parenteral, Intramuscular; Parenteral; Subcutaneous, Intramuscular; Intravenous; Subcutaneous, Injection, emulsion - Intramuscular; Intravenous; Subcutaneous, Solution, Emulsion - Intramuscular; Intravenous; Subcutaneous, Emulsion, Liquid - Intramuscular, Intramuscular, Injection, powder, lyophilized, for solution - Intravenous, Injection, solution - Intravenous, Capsule, Capsule - Oral, Solution - Parenteral, Intravenous, Injection, powder, lyophilized, for solution, Injection, solution, Injection, emulsion - Intramuscular; Parenteral; Subcutaneous, Liquid, Liquid - Intravenous, Kit, Kit - Oral, Injection - Intravenous, Injection, Solution / drops, Solution - Intramuscular; Intravenous; Subcutaneous, Solution / drops - Oral, Injection, solution - Intramuscular; Intravenous; Subcutaneous

vitamin K

, 5.0 mg, 10.0 mg/mL, 2.0 mg/mL, 1.0 mg, 0.2 mg/mL, 0.015 mg/mL, 0.15 mg/mL, 0.2 mg, 0.02 mg, 0.08 mg, 0.15 mg, 0.02 mg/mL, 0.1 mg/mL

, Tablet, Oral, Tablet - Oral, Injection, emulsion - Parenteral, Injection, emulsion, Parenteral, Intramuscular; Parenteral; Subcutaneous, Intramuscular; Intravenous; Subcutaneous, Injection, emulsion - Intramuscular; Intravenous; Subcutaneous, Solution, Emulsion - Intramuscular; Intravenous; Subcutaneous, Emulsion, Liquid - Intramuscular, Intramuscular, Injection, powder, lyophilized, for solution - Intravenous, Injection, solution - Intravenous, Capsule, Capsule - Oral, Solution - Parenteral, Intravenous, Injection, powder, lyophilized, for solution, Injection, solution, Injection, emulsion - Intramuscular; Parenteral; Subcutaneous, Liquid, Liquid - Intravenous, Kit, Kit - Oral, Injection - Intravenous, Injection, Solution / drops, Solution - Intramuscular; Intravenous; Subcutaneous, Solution / drops - Oral, Injection, solution - Intramuscular; Intravenous; Subcutaneous

Vitamin supplementation

, 5.0 mg, 10.0 mg/mL, 2.0 mg/mL, 1.0 mg, 0.2 mg/mL, 0.015 mg/mL, 0.15 mg/mL, 0.2 mg, 0.02 mg, 0.08 mg, 0.15 mg, 0.02 mg/mL, 0.1 mg/mL

, Tablet, Oral, Tablet - Oral, Injection, emulsion - Parenteral, Injection, emulsion, Parenteral, Intramuscular; Parenteral; Subcutaneous, Intramuscular; Intravenous; Subcutaneous, Injection, emulsion - Intramuscular; Intravenous; Subcutaneous, Solution, Emulsion - Intramuscular; Intravenous; Subcutaneous, Emulsion, Liquid - Intramuscular, Intramuscular, Injection, powder, lyophilized, for solution - Intravenous, Injection, solution - Intravenous, Capsule, Capsule - Oral, Solution - Parenteral, Intravenous, Injection, powder, lyophilized, for solution, Injection, solution, Injection, emulsion - Intramuscular; Parenteral; Subcutaneous, Liquid, Liquid - Intravenous, Kit, Kit - Oral, Injection - Intravenous, Injection, Solution / drops, Solution - Intramuscular; Intravenous; Subcutaneous, Solution / drops - Oral, Injection, solution - Intramuscular; Intravenous; Subcutaneous

Crohn Disease

, 5.0 mg, 10.0 mg/mL, 2.0 mg/mL, 1.0 mg, 0.2 mg/mL, 0.015 mg/mL, 0.15 mg/mL, 0.2 mg, 0.02 mg, 0.08 mg, 0.15 mg, 0.02 mg/mL, 0.1 mg/mL

, Tablet, Oral, Tablet - Oral, Injection, emulsion - Parenteral, Injection, emulsion, Parenteral, Intramuscular; Parenteral; Subcutaneous, Intramuscular; Intravenous; Subcutaneous, Injection, emulsion - Intramuscular; Intravenous; Subcutaneous, Solution, Emulsion - Intramuscular; Intravenous; Subcutaneous, Emulsion, Liquid - Intramuscular, Intramuscular, Injection, powder, lyophilized, for solution - Intravenous, Injection, solution - Intravenous, Capsule, Capsule - Oral, Solution - Parenteral, Intravenous, Injection, powder, lyophilized, for solution, Injection, solution, Injection, emulsion - Intramuscular; Parenteral; Subcutaneous, Liquid, Liquid - Intravenous, Kit, Kit - Oral, Injection - Intravenous, Injection, Solution / drops, Solution - Intramuscular; Intravenous; Subcutaneous, Solution / drops - Oral, Injection, solution - Intramuscular; Intravenous; Subcutaneous

Blood Coagulation Disorders

, 5.0 mg, 10.0 mg/mL, 2.0 mg/mL, 1.0 mg, 0.2 mg/mL, 0.015 mg/mL, 0.15 mg/mL, 0.2 mg, 0.02 mg, 0.08 mg, 0.15 mg, 0.02 mg/mL, 0.1 mg/mL

, Tablet, Oral, Tablet - Oral, Injection, emulsion - Parenteral, Injection, emulsion, Parenteral, Intramuscular; Parenteral; Subcutaneous, Intramuscular; Intravenous; Subcutaneous, Injection, emulsion - Intramuscular; Intravenous; Subcutaneous, Solution, Emulsion - Intramuscular; Intravenous; Subcutaneous, Emulsion, Liquid - Intramuscular, Intramuscular, Injection, powder, lyophilized, for solution - Intravenous, Injection, solution - Intravenous, Capsule, Capsule - Oral, Solution - Parenteral, Intravenous, Injection, powder, lyophilized, for solution, Injection, solution, Injection, emulsion - Intramuscular; Parenteral; Subcutaneous, Liquid, Liquid - Intravenous, Kit, Kit - Oral, Injection - Intravenous, Injection, Solution / drops, Solution - Intramuscular; Intravenous; Subcutaneous, Solution / drops - Oral, Injection, solution - Intramuscular; Intravenous; Subcutaneous

Celiac Disease

, 5.0 mg, 10.0 mg/mL, 2.0 mg/mL, 1.0 mg, 0.2 mg/mL, 0.015 mg/mL, 0.15 mg/mL, 0.2 mg, 0.02 mg, 0.08 mg, 0.15 mg, 0.02 mg/mL, 0.1 mg/mL

, Tablet, Oral, Tablet - Oral, Injection, emulsion - Parenteral, Injection, emulsion, Parenteral, Intramuscular; Parenteral; Subcutaneous, Intramuscular; Intravenous; Subcutaneous, Injection, emulsion - Intramuscular; Intravenous; Subcutaneous, Solution, Emulsion - Intramuscular; Intravenous; Subcutaneous, Emulsion, Liquid - Intramuscular, Intramuscular, Injection, powder, lyophilized, for solution - Intravenous, Injection, solution - Intravenous, Capsule, Capsule - Oral, Solution - Parenteral, Intravenous, Injection, powder, lyophilized, for solution, Injection, solution, Injection, emulsion - Intramuscular; Parenteral; Subcutaneous, Liquid, Liquid - Intravenous, Kit, Kit - Oral, Injection - Intravenous, Injection, Solution / drops, Solution - Intramuscular; Intravenous; Subcutaneous, Solution / drops - Oral, Injection, solution - Intramuscular; Intravenous; Subcutaneous

Jaundice, Obstructive

, 5.0 mg, 10.0 mg/mL, 2.0 mg/mL, 1.0 mg, 0.2 mg/mL, 0.015 mg/mL, 0.15 mg/mL, 0.2 mg, 0.02 mg, 0.08 mg, 0.15 mg, 0.02 mg/mL, 0.1 mg/mL

, Tablet, Oral, Tablet - Oral, Injection, emulsion - Parenteral, Injection, emulsion, Parenteral, Intramuscular; Parenteral; Subcutaneous, Intramuscular; Intravenous; Subcutaneous, Injection, emulsion - Intramuscular; Intravenous; Subcutaneous, Solution, Emulsion - Intramuscular; Intravenous; Subcutaneous, Emulsion, Liquid - Intramuscular, Intramuscular, Injection, powder, lyophilized, for solution - Intravenous, Injection, solution - Intravenous, Capsule, Capsule - Oral, Solution - Parenteral, Intravenous, Injection, powder, lyophilized, for solution, Injection, solution, Injection, emulsion - Intramuscular; Parenteral; Subcutaneous, Liquid, Liquid - Intravenous, Kit, Kit - Oral, Injection - Intravenous, Injection, Solution / drops, Solution - Intramuscular; Intravenous; Subcutaneous, Solution / drops - Oral, Injection, solution - Intramuscular; Intravenous; Subcutaneous

Vitamin K Deficiency

, 5.0 mg, 10.0 mg/mL, 2.0 mg/mL, 1.0 mg, 0.2 mg/mL, 0.015 mg/mL, 0.15 mg/mL, 0.2 mg, 0.02 mg, 0.08 mg, 0.15 mg, 0.02 mg/mL, 0.1 mg/mL

, Tablet, Oral, Tablet - Oral, Injection, emulsion - Parenteral, Injection, emulsion, Parenteral, Intramuscular; Parenteral; Subcutaneous, Intramuscular; Intravenous; Subcutaneous, Injection, emulsion - Intramuscular; Intravenous; Subcutaneous, Solution, Emulsion - Intramuscular; Intravenous; Subcutaneous, Emulsion, Liquid - Intramuscular, Intramuscular, Injection, powder, lyophilized, for solution - Intravenous, Injection, solution - Intravenous, Capsule, Capsule - Oral, Solution - Parenteral, Intravenous, Injection, powder, lyophilized, for solution, Injection, solution, Injection, emulsion - Intramuscular; Parenteral; Subcutaneous, Liquid, Liquid - Intravenous, Kit, Kit - Oral, Injection - Intravenous, Injection, Solution / drops, Solution - Intramuscular; Intravenous; Subcutaneous, Solution / drops - Oral, Injection, solution - Intramuscular; Intravenous; Subcutaneous

Hypoprothrombinemias

, 5.0 mg, 10.0 mg/mL, 2.0 mg/mL, 1.0 mg, 0.2 mg/mL, 0.015 mg/mL, 0.15 mg/mL, 0.2 mg, 0.02 mg, 0.08 mg, 0.15 mg, 0.02 mg/mL, 0.1 mg/mL

, Tablet, Oral, Tablet - Oral, Injection, emulsion - Parenteral, Injection, emulsion, Parenteral, Intramuscular; Parenteral; Subcutaneous, Intramuscular; Intravenous; Subcutaneous, Injection, emulsion - Intramuscular; Intravenous; Subcutaneous, Solution, Emulsion - Intramuscular; Intravenous; Subcutaneous, Emulsion, Liquid - Intramuscular, Intramuscular, Injection, powder, lyophilized, for solution - Intravenous, Injection, solution - Intravenous, Capsule, Capsule - Oral, Solution - Parenteral, Intravenous, Injection, powder, lyophilized, for solution, Injection, solution, Injection, emulsion - Intramuscular; Parenteral; Subcutaneous, Liquid, Liquid - Intravenous, Kit, Kit - Oral, Injection - Intravenous, Injection, Solution / drops, Solution - Intramuscular; Intravenous; Subcutaneous, Solution / drops - Oral, Injection, solution - Intramuscular; Intravenous; Subcutaneous

Intestinal resection

, 5.0 mg, 10.0 mg/mL, 2.0 mg/mL, 1.0 mg, 0.2 mg/mL, 0.015 mg/mL, 0.15 mg/mL, 0.2 mg, 0.02 mg, 0.08 mg, 0.15 mg, 0.02 mg/mL, 0.1 mg/mL

, Tablet, Oral, Tablet - Oral, Injection, emulsion - Parenteral, Injection, emulsion, Parenteral, Intramuscular; Parenteral; Subcutaneous, Intramuscular; Intravenous; Subcutaneous, Injection, emulsion - Intramuscular; Intravenous; Subcutaneous, Solution, Emulsion - Intramuscular; Intravenous; Subcutaneous, Emulsion, Liquid - Intramuscular, Intramuscular, Injection, powder, lyophilized, for solution - Intravenous, Injection, solution - Intravenous, Capsule, Capsule - Oral, Solution - Parenteral, Intravenous, Injection, powder, lyophilized, for solution, Injection, solution, Injection, emulsion - Intramuscular; Parenteral; Subcutaneous, Liquid, Liquid - Intravenous, Kit, Kit - Oral, Injection - Intravenous, Injection, Solution / drops, Solution - Intramuscular; Intravenous; Subcutaneous, Solution / drops - Oral, Injection, solution - Intramuscular; Intravenous; Subcutaneous

Hemorrhagic Disease of Newborn

, 5.0 mg, 10.0 mg/mL, 2.0 mg/mL, 1.0 mg, 0.2 mg/mL, 0.015 mg/mL, 0.15 mg/mL, 0.2 mg, 0.02 mg, 0.08 mg, 0.15 mg, 0.02 mg/mL, 0.1 mg/mL

, Tablet, Oral, Tablet - Oral, Injection, emulsion - Parenteral, Injection, emulsion, Parenteral, Intramuscular; Parenteral; Subcutaneous, Intramuscular; Intravenous; Subcutaneous, Injection, emulsion - Intramuscular; Intravenous; Subcutaneous, Solution, Emulsion - Intramuscular; Intravenous; Subcutaneous, Emulsion, Liquid - Intramuscular, Intramuscular, Injection, powder, lyophilized, for solution - Intravenous, Injection, solution - Intravenous, Capsule, Capsule - Oral, Solution - Parenteral, Intravenous, Injection, powder, lyophilized, for solution, Injection, solution, Injection, emulsion - Intramuscular; Parenteral; Subcutaneous, Liquid, Liquid - Intravenous, Kit, Kit - Oral, Injection - Intravenous, Injection, Solution / drops, Solution - Intramuscular; Intravenous; Subcutaneous, Solution / drops - Oral, Injection, solution - Intramuscular; Intravenous; Subcutaneous

Salicylate

, 5.0 mg, 10.0 mg/mL, 2.0 mg/mL, 1.0 mg, 0.2 mg/mL, 0.015 mg/mL, 0.15 mg/mL, 0.2 mg, 0.02 mg, 0.08 mg, 0.15 mg, 0.02 mg/mL, 0.1 mg/mL

, Tablet, Oral, Tablet - Oral, Injection, emulsion - Parenteral, Injection, emulsion, Parenteral, Intramuscular; Parenteral; Subcutaneous, Intramuscular; Intravenous; Subcutaneous, Injection, emulsion - Intramuscular; Intravenous; Subcutaneous, Solution, Emulsion - Intramuscular; Intravenous; Subcutaneous, Emulsion, Liquid - Intramuscular, Intramuscular, Injection, powder, lyophilized, for solution - Intravenous, Injection, solution - Intravenous, Capsule, Capsule - Oral, Solution - Parenteral, Intravenous, Injection, powder, lyophilized, for solution, Injection, solution, Injection, emulsion - Intramuscular; Parenteral; Subcutaneous, Liquid, Liquid - Intravenous, Kit, Kit - Oral, Injection - Intravenous, Injection, Solution / drops, Solution - Intramuscular; Intravenous; Subcutaneous, Solution / drops - Oral, Injection, solution - Intramuscular; Intravenous; Subcutaneous

Cystic Fibrosis

, 5.0 mg, 10.0 mg/mL, 2.0 mg/mL, 1.0 mg, 0.2 mg/mL, 0.015 mg/mL, 0.15 mg/mL, 0.2 mg, 0.02 mg, 0.08 mg, 0.15 mg, 0.02 mg/mL, 0.1 mg/mL

, Tablet, Oral, Tablet - Oral, Injection, emulsion - Parenteral, Injection, emulsion, Parenteral, Intramuscular; Parenteral; Subcutaneous, Intramuscular; Intravenous; Subcutaneous, Injection, emulsion - Intramuscular; Intravenous; Subcutaneous, Solution, Emulsion - Intramuscular; Intravenous; Subcutaneous, Emulsion, Liquid - Intramuscular, Intramuscular, Injection, powder, lyophilized, for solution - Intravenous, Injection, solution - Intravenous, Capsule, Capsule - Oral, Solution - Parenteral, Intravenous, Injection, powder, lyophilized, for solution, Injection, solution, Injection, emulsion - Intramuscular; Parenteral; Subcutaneous, Liquid, Liquid - Intravenous, Kit, Kit - Oral, Injection - Intravenous, Injection, Solution / drops, Solution - Intramuscular; Intravenous; Subcutaneous, Solution / drops - Oral, Injection, solution - Intramuscular; Intravenous; Subcutaneous

Celiac Disease

, 5.0 mg, 10.0 mg/mL, 2.0 mg/mL, 1.0 mg, 0.2 mg/mL, 0.015 mg/mL, 0.15 mg/mL, 0.2 mg, 0.02 mg, 0.08 mg, 0.15 mg, 0.02 mg/mL, 0.1 mg/mL

, Tablet, Oral, Tablet - Oral, Injection, emulsion - Parenteral, Injection, emulsion, Parenteral, Intramuscular; Parenteral; Subcutaneous, Intramuscular; Intravenous; Subcutaneous, Injection, emulsion - Intramuscular; Intravenous; Subcutaneous, Solution, Emulsion - Intramuscular; Intravenous; Subcutaneous, Emulsion, Liquid - Intramuscular, Intramuscular, Injection, powder, lyophilized, for solution - Intravenous, Injection, solution - Intravenous, Capsule, Capsule - Oral, Solution - Parenteral, Intravenous, Injection, powder, lyophilized, for solution, Injection, solution, Injection, emulsion - Intramuscular; Parenteral; Subcutaneous, Liquid, Liquid - Intravenous, Kit, Kit - Oral, Injection - Intravenous, Injection, Solution / drops, Solution - Intramuscular; Intravenous; Subcutaneous, Solution / drops - Oral, Injection, solution - Intramuscular; Intravenous; Subcutaneous

antibacterial therapy

, 5.0 mg, 10.0 mg/mL, 2.0 mg/mL, 1.0 mg, 0.2 mg/mL, 0.015 mg/mL, 0.15 mg/mL, 0.2 mg, 0.02 mg, 0.08 mg, 0.15 mg, 0.02 mg/mL, 0.1 mg/mL

, Tablet, Oral, Tablet - Oral, Injection, emulsion - Parenteral, Injection, emulsion, Parenteral, Intramuscular; Parenteral; Subcutaneous, Intramuscular; Intravenous; Subcutaneous, Injection, emulsion - Intramuscular; Intravenous; Subcutaneous, Solution, Emulsion - Intramuscular; Intravenous; Subcutaneous, Emulsion, Liquid - Intramuscular, Intramuscular, Injection, powder, lyophilized, for solution - Intravenous, Injection, solution - Intravenous, Capsule, Capsule - Oral, Solution - Parenteral, Intravenous, Injection, powder, lyophilized, for solution, Injection, solution, Injection, emulsion - Intramuscular; Parenteral; Subcutaneous, Liquid, Liquid - Intravenous, Kit, Kit - Oral, Injection - Intravenous, Injection, Solution / drops, Solution - Intramuscular; Intravenous; Subcutaneous, Solution / drops - Oral, Injection, solution - Intramuscular; Intravenous; Subcutaneous

Warnings

Vitamin K1 Contraindications

Condition

Risk Level

Notes

Severe Hypersensitivity Reactions

Do Not Combine

Phylloquinone may interact with Pulse Frequency

There are 20 known major drug interactions with Vitamin K1.

Common Vitamin K1 Drug Interactions

Drug Name

Risk Level

Description

(R)-warfarin

Major

The therapeutic efficacy of (R)-warfarin can be decreased when used in combination with Phylloquinone.

(S)-Warfarin

Major

The therapeutic efficacy of (S)-Warfarin can be decreased when used in combination with Phylloquinone.

4-hydroxycoumarin

Major

The therapeutic efficacy of 4-hydroxycoumarin can be decreased when used in combination with Phylloquinone.

Acenocoumarol

Major

The therapeutic efficacy of Acenocoumarol can be decreased when used in combination with Phylloquinone.

Clorindione

Major

The therapeutic efficacy of Clorindione can be decreased when used in combination with Phylloquinone.

Vitamin K1 Toxicity & Overdose Risk

Taking too much vitamin K1 can be dangerous, especially when given through an IV. The toxic dose of vitamin K1 for mice is 1170 mg/kg when given intravenously and more than 24180 mg/kg when given orally. If someone overdoses on vitamin K1, they should be treated with supportive care.

image of a doctor in a lab doing drug, clinical research

Vitamin K1 Novel Uses: Which Conditions Have a Clinical Trial Featuring Vitamin K1?

At present, 100 active studies are in progress to evaluate the potential of Vitamin K1 in addressing Crohn Disease, Hemorrhagic Disease of the Newborn and Obstructive Jaundice.

Condition

Clinical Trials

Trial Phases

Ulcerative Colitis

26 Actively Recruiting

Phase 3, Phase 2, Phase 1, Not Applicable, Phase 4

Jaundice, Obstructive

0 Actively Recruiting

Blood Coagulation Disorders

1 Actively Recruiting

Phase 1

Cystic Fibrosis

0 Actively Recruiting

Vitamin K Deficiency

0 Actively Recruiting

Vitamin supplementation

0 Actively Recruiting

Crohn Disease

0 Actively Recruiting

antibacterial therapy

0 Actively Recruiting

Hemorrhagic Disease of Newborn

0 Actively Recruiting

Celiac Disease

0 Actively Recruiting

Hypoprothrombinemias

0 Actively Recruiting

vitamin K

0 Actively Recruiting

hemorrhagic disease of the newborn

0 Actively Recruiting

Vitamin supplementation therapy

0 Actively Recruiting

long-acting anticoagulant rodenticides

0 Actively Recruiting

Celiac Disease

0 Actively Recruiting

Salicylate

0 Actively Recruiting

Anticoagulant Therapy

2 Actively Recruiting

Phase 4, Not Applicable

Intestinal resection

0 Actively Recruiting

Biliary Fistula

0 Actively Recruiting

Patient Q&A Section about vitamin k1

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Which is better to take vitamin K1 or K2?

"Several studies have suggested that vitamin K2 is better than K1 at reducing calcium deposits and lowering your risk of heart disease."

Answered by AI

Is vitamin K1 the same as vitamin K?

"Vitamin K1 is the main form of vitamin K in the diet. It's found in green vegetables and in plant chlorophylls. Vitamin K2 is made by bacteria and is found in food where bacteria are part of the production process."

Answered by AI

What is vitamin K1 and K2 good for?

"There are two types of vitamin K, K1 and K2. Both are important for blood clotting and preventing excessive bruising and bleeding. However, recent research suggests that K2 may offer additional health benefits beyond those of K1."

Answered by AI

What is vitamin K1 used for?

"Vitamin K is essential for blood clotting, bone building, and other important processes. There are two main types of vitamin K: K1 (phytonadione) and K2 (menaquinone). Vitamin K1 is found in green vegetables, while vitamin K2 is commonly available as a supplement."

Answered by AI

Clinical Trials for Vitamin K1

Image of GI PROS, Inc. in Naples, United States.

MGT-006 for Ulcerative Colitis

18 - 75
All Sexes
Naples, FL

Ulcerative colitis is a condition that causes inflammation and ulcers in the large intestine. MGT-006 is an investigational oral capsule containing viable gut microbiota from screened human donors. This study will evaluate the safety and tolerability of MGT-006 in adults with moderately active ulcerative colitis. It will also examine whether gut microbiota from MGT-006 engraft in participants' intestines and explore changes in ulcerative colitis symptoms and inflammation. The study has two parts. In Phase 1b, participants will be randomly assigned to receive MGT-006 either without antibiotic pretreatment or after five days of oral vancomycin or AFM (Amoxicillin/Fosfomycin/Metronidazole) pretreatment. MGT-006 will be taken for eight weeks, followed by four weeks of observation. Phase 2a is planned to explore different doses and potentially different dosing regimens of MGT-006, using the pretreatment approach selected from Phase 1b. The final Phase 2a design will depend on the Phase 1b findings and will be specified in an amended protocol before Phase 2a begins.

Phase 1 & 2
Recruiting

GI PROS, Inc. (+2 Sites)

Metagen Therapeutics, Inc.

Image of University of Chicago in Chicago, United States.

Virtual Group Therapy for Inflammatory Bowel Disease

18+
All Sexes
Chicago, IL

This study is being done to better understand the complex relationship between mental health and Inflammatory Bowel Disease (IBD), with a particular focus on symptoms of depression and anxiety. While depression and anxiety have traditionally been viewed as reactions to the burden of living with IBD, new research suggests that the biological factors involved in IBD may also contribute directly to these mental health challenges. This study aims to evaluate whether a virtual, group-based psychological treatment is both acceptable and feasible for patients with IBD who experience significant depression and/or anxiety. Researchers will also evaluate participants' depression, generalized anxiety, and associated psychosocial factors (poor sleep quality, GI-specific anxiety, fatigue) before, during, and after treatment. Finally, researchers will evaluate disease severity as it relates to mental health status by comparing it to symptoms, biochemical disease and tryptophan metabolites from blood and stool samples. People who agree to join the study will be asked to attend three in-person visits and 10 virtual group psychotherapy sessions over 11 weeks. Participants will be asked to complete questionnaires, give stool and blood samples, and the research team will collect information about participations from medical records.

Waitlist Available
Has No Placebo

University of Chicago

Alyse Bedell, PhD, CST

Have you considered Vitamin K1 clinical trials?

We made a collection of clinical trials featuring Vitamin K1, we think they might fit your search criteria.
Go to Trials
Image of Mount Sinai Hospital in Toronto, Canada.

Blood Thinners for Pregnancy with Mechanical Heart Valves

18 - 45
Female
Toronto, Canada

The purpose of this pilot study is to collect data on pregnancies with mechanical heart valves to see if using a blood thinner called low molecular weight heparin (LMWH) and low dose aspirin (LDA) is comparable to warfarin/vitamin K antagonist (VKA) to reduce the chance of clotting around the mechanical valve and improve survival. The study is a pilot study as the study investigators need to ensure that the blood levels needed for adequate amounts of LMWH and warfarin can be maintained during pregnancy to be able to compare LMWH and aspirin to warfarin. If this study shows that we can collect the tests that are needed for a larger study, the individuals' information who participated in this pilot study will be moved to the larger study. The larger study will compare survival, clot development and cardiac function as well as safety of these two common blood thinners.

Recruiting
Has No Placebo

Mount Sinai Hospital

Image of University of British Columbia-Okanagan in Kelowna, Canada.

Dietary Therapy for Ulcerative Colitis

19 - 70
All Sexes
Kelowna, Canada

This study aims to test whether a short liquid-based diet, followed by a low-sulfur eating plan, is safe, manageable, and helpful for people with mild to moderate ulcerative colitis. Investigators want to see if this approach can improve gut health, lower inflammation, and reduce symptoms. Investigators will also test breath samples as an easy, non-invasive way to track gut bacteria activity and disease changes. Investigators believe this diet plan can reduce harmful gut bacteria that produce irritating sulfur compounds, leading to better gut health and measurable improvements that can be detected through breath testing.

Waitlist Available
Has No Placebo

University of British Columbia-Okanagan

Natasha Haskey, RD, PhD

Have you considered Vitamin K1 clinical trials?

We made a collection of clinical trials featuring Vitamin K1, we think they might fit your search criteria.
Go to Trials
Image of Resilient Roots: Functional Medicine in Charlottesville, United States.

Ketogenic and Carnivore Diets for Inflammatory Bowel Disease and Rheumatoid Arthritis

18 - 64
All Sexes
Charlottesville, VA

This study is a randomized controlled clinical trial evaluating whether two therapeutic dietary approaches - a ketogenic diet and a carnivore (lion) diet - can improve quality of life, reduce symptoms, and influence measures of disease activity in adults with inflammatory bowel disease \[ulcerative colitis and Crohn's disease\] (IBD) or rheumatoid arthritis (RA). Participants will be randomized into one of three groups: 1) Ketogenic Diet, 2) Carnivore (Lion) Diet or 3) Wait-List Control. Participants randomized to a dietary group (ketogenic diet or carnivore diet) will be provided guidance on their specific dietary therapy and answer questions about their symptoms and quality of life at different intervals over a 24 week period. Participants will also complete laboratory testing at different intervals to assess for changes in nutritional status, cardiometabolic health and markers of immune activation and inflammation. Participants initially placed on the wait-list group will be asked similar questions about their symptoms and quality of life and complete the same laboratory testing as participants in a dietary group. Participants on the wait list will then be compared to participants following a specific dietary pattern to assess for any differences between the 2 groups. After 12 weeks, participants on the wait list will be randomized to a dietary group (ketogenic diet or carnivore diet) and followed in a similar fashion for an additional 12 week period.

Recruiting
Has No Placebo

Resilient Roots: Functional Medicine

Robert D Abbott, MD

Image of UCSF Medical Center in San Francisco, United States.

Upadacitinib for Ulcerative Colitis

18 - 75
All Sexes
San Francisco, CA

The goal of this clinical trial is to learn if the oral medication upadacitinib can safely and effectively treat acute severe ulcerative colitis (ASUC) in adults who are hospitalized. It will also evaluate whether upadacitinib can be used without corticosteroids during initial treatment. The main questions it aims to answer are: 1. Does upadacitinib reduce treatment failure by Day 14 (defined as need for colectomy or rescue therapy)? 2. What side effects and safety events occur when using upadacitinib in hospitalized patients with ASUC? Researchers will compare outcomes in participants receiving upadacitinib to a historical group of similar patients previously treated with standard therapies, including intravenous corticosteroids and infliximab, to determine if upadacitinib improves outcomes. Participants will: 1. Take oral upadacitinib once daily during hospitalization. 2. Undergo routine clinical monitoring, including blood tests and symptom assessments. 3. Be followed after discharge with clinic visits or phone calls for up to 12 months to assess outcomes such as need for additional treatment, surgery, and safety events

Phase 4
Waitlist Available

UCSF Medical Center

Sara Lewin, MD

AbbVie

Have you considered Vitamin K1 clinical trials?

We made a collection of clinical trials featuring Vitamin K1, we think they might fit your search criteria.
Go to Trials