Tatjana Kolevska, MD, discusses cancer ...

Dr. Tatjana Kolevska, MD

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Kaiser Permanente-Vallejo

Studies Cancer
Studies Cutaneous Melanoma
22 reported clinical trials
52 drugs studied

Area of expertise

1

Cancer

Tatjana Kolevska, MD has run 5 trials for Cancer. Some of their research focus areas include:

Stage IV
Stage II
Stage III
2

Cutaneous Melanoma

Tatjana Kolevska, MD has run 5 trials for Cutaneous Melanoma. Some of their research focus areas include:

Stage IV
Stage III
BRAF positive

Affiliated Hospitals

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Kaiser Permanente-Vallejo

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Kaiser Permanente-Santa Teresa-San Jose

Clinical Trials Tatjana Kolevska, MD is currently running

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Chemotherapy + Immunotherapy

for Esophageal and Gastric Cancer

This phase III trial compares the effect of modified fluorouracil, leucovorin calcium, oxaliplatin, and irinotecan (mFOLFIRINOX) with or without nivolumab to the effect of modified fluorouracil, leucovorin calcium, and oxaliplatin (mFOLFOX) with or without nivolumab for the treatment of patients with advanced, unresectable, or metastatic HER2 negative esophageal, gastroesophageal junction, or gastric adenocarcinoma. The usual approach for patients who are not in a study is treatment with FOLFOX with some receiving an immunotherapy drug, either nivolumab or pembrolizumab, in addition to FOLFOX chemotherapy. The usual approach is defined as care most people get for cancer in the stomach, esophagus, or gastroesophageal junction. Fluorouracil is in a class of medications called antimetabolites. It stops cells from making DNA and may kill tumor cells. Leucovorin in a class of medications called folic acid analogs. When used with fluorouracil it enhances the effects of this chemotherapy drug. Irinotecan is in a class of antineoplastic medications called topoisomerase I inhibitors. It blocks a certain enzyme needed for cell division and DNA repair, and may kill cancer cells. Oxaliplatin is in a class of medications called platinum-containing antineoplastic agents. It damages the cell's DNA and may kill cancer cells. Immunotherapy with monoclonal antibodies, such as nivolumab, may help the body's immune system attack the cancer and may interfere with the ability of tumor cells to grow and spread. Some patients on this trial will receive nivolumab, in addition to mFOLFOX or mFOLFIRINOX chemotherapy. mFOLFIRINOX with or without nivolumab may be more effective than mFOLFOX with or without nivolumab by shrinking the tumor in patients with advanced, unresectable, or metastatic HER2-negative esophageal, gastroesophageal junction, or gastric adenocarcinoma.

Recruiting

2 awards

Phase 3

2 criteria

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Multiple Targeted Therapies

for Meningioma

This trial studies four drugs to treat patients with worsening meningioma. These drugs work by blocking enzymes that the tumor cells need to grow. The trial focuses on patients whose tumors have specific genetic mutations.

Recruiting

1 award

Phase 2

10 criteria

More about Tatjana Kolevska, MD

Clinical Trial Related

3 years of experience running clinical trials · Led 22 trials as a Principal Investigator · 5 Active Clinical Trials

Treatments Tatjana Kolevska, MD has experience with

  • Nivolumab
  • Ipilimumab
  • Pembrolizumab
  • Lenalidomide
  • MFOLFIRINOX
  • Carboplatin

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