Dr. Tanner M Johanns, M.D., Ph.D.
Claim this profileWashington University School of Medicine
Area of expertise
Glioblastoma
Tanner M Johanns, M.D., Ph.D. has run 8 trials for Glioblastoma. Some of their research focus areas include:
Brain Tumor
Tanner M Johanns, M.D., Ph.D. has run 8 trials for Brain Tumor. Some of their research focus areas include:
Affiliated Hospitals
Washington University School Of Medicine
Siteman Cancer Center At West County Hospital
Clinical Trials Tanner M Johanns, M.D., Ph.D. is currently running
Nivolumab
for Cancer
This phase Ib trial studies the side effects of nivolumab and to see how well it works alone and in combination with other treatments, such as ipilimumab, cabozantinib, platinum containing therapy, and fluoropyrimidine, in treating patients with autoimmune disorders and cancer that has spread from where it first started (primary site) to nearby tissue, lymph nodes, or distant parts of the body (advanced), to other places in the body (metastatic) or cannot removed by surgery (unresectable). Immunotherapy with monoclonal antibodies, such as nivolumab and ipilimumab, may help the body's immune system attack the cancer, and may interfere with the ability of tumor cells to grow and spread. Cabozantinib blocks certain proteins, which may help keep tumor cells from growing. It may also prevent the growth of new blood vessels that tumors need to grow. Cabozantinib is a type of tyrosine kinase inhibitor and a type of angiogenesis inhibitor. Chemotherapy drugs, such as platinum containing therapies and fluoropyrimidine, work in different ways to stop the growth of tumor cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. Giving nivolumab alone and in combination with other treatments, including ipilimumab, cabozantinib, platinum containing therapy, or fluoropyrimidine, may be safe, tolerable, and/or effective in treating patients with autoimmune disorders and advanced, metastatic, or unresectable cancer.
Recruiting
1 award
Phase 1
20 criteria
Azeliragon + Chemoradiotherapy
for Glioblastoma
Preclinical data have demonstrated the combination of azeliragon, a RAGE inhibitor, with radiation therapy (RT) can effectively reduce immune-suppressive myeloid cells and restore T-cell activation to improve tumor control in murine glioma models. Ongoing clinical studies of azeliragon with RT alone and RT plus temozolomide (TMZ) to treat patients with newly diagnosed glioblastoma (GBM) have demonstrated safety and tolerability. The purpose of this window-of-opportunity study is to validate that the combination of azeliragon with RT and TMZ would modulate immune-suppressive myeloid and T cells in the tumor microenvironment in patients with GBM.
Recruiting
1 award
Phase < 1
6 criteria
More about Tanner M Johanns, M.D., Ph.D.
Clinical Trial Related
4 years of experience running clinical trials · Led 24 trials as a Principal Investigator · 4 Active Clinical Trials
Treatments Tanner M Johanns, M.D., Ph.D. has experience with
- Nivolumab
- Retifanlimab
- Pembrolizumab
- Ipilimumab
- Personalized Neoantigen DNA Vaccine
- Surgery
Breakdown of trials Tanner M Johanns, M.D., Ph.D. has run
Glioblastoma
Brain Tumor
Solid Tumors
Astrocytoma
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Frequently asked questions
Do I need insurance to participate in a trial?
Almost all clinical trials will cover the cost of the ‘trial drug’ — so no insurance is required for this. For trials where this trial drug is given alongside an already-approved medication, there may be a cost (which your insurance would normally cover).
What does Tanner M Johanns, M.D., Ph.D. specialize in?
Tanner M Johanns, M.D., Ph.D. focuses on Glioblastoma and Brain Tumor. In particular, much of their work with Glioblastoma has involved IDH negative patients, or patients who are Stage IV.
Is Tanner M Johanns, M.D., Ph.D. currently recruiting for clinical trials?
Yes, Tanner M Johanns, M.D., Ph.D. is currently recruiting for 4 clinical trials in Saint Louis Missouri. If you're interested in participating, you should apply.
Are there any treatments that Tanner M Johanns, M.D., Ph.D. has studied deeply?
Yes, Tanner M Johanns, M.D., Ph.D. has studied treatments such as Nivolumab, Retifanlimab, Pembrolizumab.
What is the best way to schedule an appointment with Tanner M Johanns, M.D., Ph.D.?
Apply for one of the trials that Tanner M Johanns, M.D., Ph.D. is conducting.
What is the office address of Tanner M Johanns, M.D., Ph.D.?
The office of Tanner M Johanns, M.D., Ph.D. is located at: Washington University School of Medicine, Saint Louis, Missouri 63110 United States. This is the address for their practice at the Washington University School of Medicine.
Is there any support for travel costs?
The coverage of travel expenses can vary greatly between different clinical trials. Please see more financial detail in the trials you’re interested to apply.
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