Dr. Ryan Lynch, MD

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Fred Hutch/University of Washington Cancer Consortium

Studies Non-Hodgkin's Lymphoma
Studies Hodgkin's Lymphoma
9 reported clinical trials
23 drugs studied

Area of expertise

1

Non-Hodgkin's Lymphoma

Ryan Lynch, MD has run 5 trials for Non-Hodgkin's Lymphoma.

2

Hodgkin's Lymphoma

Ryan Lynch, MD has run 4 trials for Hodgkin's Lymphoma. Some of their research focus areas include:

Stage I
Stage IV
Stage III

Affiliated Hospitals

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Fred Hutch/University Of Washington Cancer Consortium

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Seattle Cancer Care Alliance / University Of Washington

Clinical Trials Ryan Lynch, MD is currently running

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Cema-cel

for B-Cell Lymphoma

This is a randomized, open-label study in adult patients who have completed standard first line therapy for large B-cell lymphoma (LBCL) and achieved a complete response or partial response suitable for observation, but who have minimal residual disease (MRD) as detected by the Foresight CLARITY™ Investigational Use Only (IUO) MRD test, powered by PhasED-Seq™. The purpose of the trial is to assess the efficacy and safety of consolidation with cemacabtagene ansegedleucel (cema-cel), an allogeneic CD19 CAR T product, as compared to standard of care observation. In this study, participants with MRD are randomized 1:1 to treatment with cema-cel or an observation arm. Treatment includes cema-cel following a lymphodepletion regimen of fludarabine and cyclophosphamide. Prior to August 2025, participants may also have received an anti-CD52 monoclonal antibody, ALLO-647, as part of their lymphodepletion regimen.

Recruiting

1 award

Phase 2

5 criteria

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Personalized Chemotherapy

for Hodgkin's Lymphoma

This phase II trial tests how well personalized reduction of chemotherapy (nivolumab, doxorubicin, vinblastine and dacarbazine) based on circulating tumor deoxyribonucleic acid (ctDNA) evaluation works for treating patients with Hodgkin lymphoma that may have spread from where it first started to nearby tissue, lymph nodes, or distant parts of the body (advanced). Chemotherapy drugs, such as nivolumab, doxorubicin, vinblastine and dacarbazine, work in different ways to stop the growth of tumor cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. Many types of tumors tend to lose cells or release different types of cellular products including their DNA, which is referred to as ctDNA, into the bloodstream before changes can be seen on scans. Health care providers can measure the level of ctDNA in blood or other bodily fluids and, based on the result, assign patients to a reduced number of chemotherapy treatments or the standard number of chemotherapy treatments. Using ctDNA to assign a personalized reduction of chemotherapy may be effective in treating patients with advanced Hodgkin lymphoma.

Recruiting

1 award

Phase 2

5 criteria

More about Ryan Lynch, MD

Clinical Trial Related

6 years of experience running clinical trials · Led 9 trials as a Principal Investigator · 2 Active Clinical Trials

Treatments Ryan Lynch, MD has experience with

  • Dacarbazine
  • Doxorubicin
  • Rituximab
  • Nivolumab
  • Vinblastine
  • Polatuzumab Vedotin

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