Dr. Patrick A. Brown
Claim this profileJohns Hopkins University/Sidney Kimmel Cancer Center
Area of expertise
Burkitt's Leukemia
Patrick A. Brown has run 6 trials for Burkitt's Leukemia. Some of their research focus areas include:
Leukemia
Patrick A. Brown has run 5 trials for Leukemia. Some of their research focus areas include:
Affiliated Hospitals
Johns Hopkins University/Sidney Kimmel Cancer Center
Johns Hopkins Hospital
Clinical Trials Patrick A. Brown is currently running
Inotuzumab Ozogamicin
for Acute Lymphoblastic Leukemia
This phase III trial studies whether inotuzumab ozogamicin added to post-induction chemotherapy and immunotherapy (chemo-immunotherapy) for patients with High-Risk B-cell Acute Lymphoblastic Leukemia (B-ALL) improves outcomes. Inotuzumab ozogamicin is a monoclonal antibody, which is a type of protein that can bind to certain targets on the surface of cells. Inotuzumab ozogamicin is a monoclonal antibody that is linked to a type of chemotherapy called calicheamicin. Inotuzumab attaches to cancer cells by binding to the CD22 protein on the surface of the cancer cell and delivering calicheamicin inside the cells to kill them. Other drugs used in the chemotherapy regimen, such as cyclophosphamide, cytarabine, dexamethasone, doxorubicin, daunorubicin, methotrexate, leucovorin, mercaptopurine, prednisone, thioguanine, vincristine, and pegaspargase or calaspargase pegol work in different ways to stop the growth of cancer cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. Blinatumomab is a specialized type of monoclonal antibody known as a bispecific T-cell engager (BiTE). It works by simultaneously binding to CD19 on cancer cells and CD3 on normal immune cells, bringing them together to destroy leukemia cells. Blinatumomab is a standard part of chemo-immunotherapy treatment for B-ALL. This trial also studies the outcomes of patients with mixed phenotype acute leukemia (MPAL), and B-lymphoblastic lymphoma (B-LLy) when treated with ALL therapy without inotuzumab ozogamicin or blinatumomab. The overall goal of this study is to understand if adding inotuzumab ozogamicin to standard of care chemo-immunotherapy maintains or improves outcomes in High Risk B-cell Acute Lymphoblastic Leukemia (HR B-ALL). The first part of the study includes the first phase of therapy: Induction. This part will collect information on the leukemia, as well as the effects of the initial treatment, to classify patients into post-induction treatment groups. On the second part of this study, patients with HR B-ALL will receive the remainder of the chemotherapy cycles (consolidation, blinatumomab block 1, interim maintenance 1, blinatumomab block 2, delayed intensification, interim maintenance 2, maintenance), with some patients randomized to receive inotuzumab. The patients that receive inotuzumab will not receive part of consolidation or part of delayed intensification. Other aims of this study include evaluating 1) side effects of treatment using patient-reported outcomes and health-related quality of life, 2) the best ways to help patients adhere to oral chemotherapy regimens, 3) the relationship between levels of inotuzumab ozogamicin in the blood and side effects, 4) the impact of chemo-immunotherapy on the immune system and risk of infection, and 5) the impact of social determinants of health on outcomes. Finally, this study will be the first to track the outcomes of subjects with disseminated B-cell Lymphoblastic Leukemia (B-LLy) or Mixed Phenotype Acute Leukemia (MPAL) when treated with B-ALL chemotherapy.
Recruiting
2 awards
Phase 3
Caloric Restriction + Activity
for Acute Lymphoblastic Leukemia
This trial tests if a personalized diet and exercise plan can help older children, adolescents, and young adults with high-risk B-cell Acute Lymphoblastic Leukemia respond better to chemotherapy. The plan aims to reduce body fat, which is linked to treatment resistance, and limit fat gain during chemotherapy.
Recruiting
1 award
Phase 2
More about Patrick A. Brown
Clinical Trial Related
6 years of experience running clinical trials · Led 11 trials as a Principal Investigator · 2 Active Clinical Trials
Treatments Patrick A. Brown has experience with
- Cytarabine
- Dexamethasone
- Cyclophosphamide
- Daunorubicin Hydrochloride
- Pegaspargase
- Prednisolone
Breakdown of trials Patrick A. Brown has run
Burkitt's Leukemia
Leukemia
Acute Lymphoblastic Leukemia
Acute Myeloid Leukemia
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Frequently asked questions
Do I need insurance to participate in a trial?
Almost all clinical trials will cover the cost of the ‘trial drug’ — so no insurance is required for this. For trials where this trial drug is given alongside an already-approved medication, there may be a cost (which your insurance would normally cover).
What does Patrick A. Brown specialize in?
Patrick A. Brown focuses on Burkitt's Leukemia and Leukemia. In particular, much of their work with Burkitt's Leukemia has involved Philadelphia chromosome positive patients, or patients who are BCR-ABL1 fusion positive.
Is Patrick A. Brown currently recruiting for clinical trials?
Yes, Patrick A. Brown is currently recruiting for 2 clinical trials in Baltimore Maryland. If you're interested in participating, you should apply.
Are there any treatments that Patrick A. Brown has studied deeply?
Yes, Patrick A. Brown has studied treatments such as Cytarabine, Dexamethasone, Cyclophosphamide.
What is the best way to schedule an appointment with Patrick A. Brown?
Apply for one of the trials that Patrick A. Brown is conducting.
What is the office address of Patrick A. Brown?
The office of Patrick A. Brown is located at: Johns Hopkins University/Sidney Kimmel Cancer Center, Baltimore, Maryland 21287 United States. This is the address for their practice at the Johns Hopkins University/Sidney Kimmel Cancer Center.
Is there any support for travel costs?
The coverage of travel expenses can vary greatly between different clinical trials. Please see more financial detail in the trials you’re interested to apply.
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