Nicholas J. DiBella, MD (Medical ...

Dr. Nicholas DiBella

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Rocky Mountain Cancer Centers-Boulder

Expert in Breast Cancer
Expert in Lung Cancer
103 reported clinical trials
193 drugs studied

About Nicholas DiBella

Education:

  • Earned a Medical degree (MD) from an unspecified institution.

Experience:

  • Founded Rocky Mountain Cancer Centers (RMCC) in 1992 and served as its former president.
  • Served as Chairman of the Board for the Colorado Cancer Research Program.
  • Held the position of Chairman for the US Oncology Hematology Research Committee.
  • Played a key role in establishing The US Oncology Network, connecting over 1,400 oncologists nationwide.
  • Retired as Medical Director at Rocky Mountain Breast Specialists.

Area of expertise

1

Breast Cancer

Global Leader

Nicholas DiBella has run 19 trials for Breast Cancer. Some of their research focus areas include:

Stage IV
HER2 positive
ER positive
2

Lung Cancer

Global Leader

Nicholas DiBella has run 18 trials for Lung Cancer. Some of their research focus areas include:

Stage IV
Stage III
Stage II

Affiliated Hospitals

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Rocky Mountain Cancer Centers-Boulder

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Rocky Mountain Cancer Centers-Aurora

Clinical Trials Nicholas DiBella is currently running

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Chemotherapy + Immunotherapy

for Esophageal and Gastric Cancer

This phase III trial compares the effect of modified fluorouracil, leucovorin calcium, oxaliplatin, and irinotecan (mFOLFIRINOX) with or without nivolumab to the effect of modified fluorouracil, leucovorin calcium, and oxaliplatin (mFOLFOX) with or without nivolumab for the treatment of patients with advanced, unresectable, or metastatic HER2 negative esophageal, gastroesophageal junction, or gastric adenocarcinoma. The usual approach for patients who are not in a study is treatment with FOLFOX with some receiving an immunotherapy drug, either nivolumab or pembrolizumab, in addition to FOLFOX chemotherapy. The usual approach is defined as care most people get for cancer in the stomach, esophagus, or gastroesophageal junction. Fluorouracil is in a class of medications called antimetabolites. It stops cells from making DNA and may kill tumor cells. Leucovorin in a class of medications called folic acid analogs. When used with fluorouracil it enhances the effects of this chemotherapy drug. Irinotecan is in a class of antineoplastic medications called topoisomerase I inhibitors. It blocks a certain enzyme needed for cell division and DNA repair, and may kill cancer cells. Oxaliplatin is in a class of medications called platinum-containing antineoplastic agents. It damages the cell's DNA and may kill cancer cells. Immunotherapy with monoclonal antibodies, such as nivolumab, may help the body's immune system attack the cancer and may interfere with the ability of tumor cells to grow and spread. Some patients on this trial will receive nivolumab, in addition to mFOLFOX or mFOLFIRINOX chemotherapy. mFOLFIRINOX with or without nivolumab may be more effective than mFOLFOX with or without nivolumab by shrinking the tumor in patients with advanced, unresectable, or metastatic HER2-negative esophageal, gastroesophageal junction, or gastric adenocarcinoma.

Recruiting

2 awards

Phase 3

2 criteria

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Osimertinib + Bevacizumab

for Lung Cancer

This phase III trial compares the effect of bevacizumab and osimertinib combination vs. osimertinib alone for the treatment of non-small cell lung cancer that has spread outside of the lungs (stage IIIB-IV) and has a change (mutation) in a gene called EGFR. The EGFR protein is involved in cell signaling pathways that control cell division and survival. Sometimes, mutations in the EGFR gene cause EGFR proteins to be made in higher than normal amounts on some types of cancer cells. This causes cancer cells to divide more rapidly. Osimertinib may stop the growth of tumor cells by blocking EGFR that is needed for cell growth in this type of cancer. Bevacizumab is in a class of medications called antiangiogenic agents. It works by stopping the formation of blood vessels that bring oxygen and nutrients to tumor. This may slow the growth and spread of tumor. Giving osimertinib with bevacizumab may control cancer for longer and help patients live longer as compared to osimertinib alone.

Recruiting

2 awards

Phase 3

31 criteria

More about Nicholas DiBella

Clinical Trial Related

7 years of experience running clinical trials · Led 103 trials as a Principal Investigator · 17 Active Clinical Trials

Treatments Nicholas DiBella has experience with

  • Nivolumab
  • Pembrolizumab
  • Cisplatin
  • Atezolizumab
  • Intensity-Modulated Radiation Therapy
  • Fluorouracil

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