Dr. Melinda Pauly, MD
Claim this profileChildren's Healthcare of Atlanta
Area of expertise
Acute Myeloid Leukemia
Melinda Pauly, MD has run 5 trials for Acute Myeloid Leukemia. Some of their research focus areas include:
Leukemia
Melinda Pauly, MD has run 5 trials for Leukemia. Some of their research focus areas include:
Affiliated Hospitals
Children's Healthcare Of Atlanta
Children's Healthcare Of Atlanta - Egleston
Clinical Trials Melinda Pauly, MD is currently running
Caloric Restriction + Activity
for Acute Lymphoblastic Leukemia
This trial tests if a personalized diet and exercise plan can help older children, adolescents, and young adults with high-risk B-cell Acute Lymphoblastic Leukemia respond better to chemotherapy. The plan aims to reduce body fat, which is linked to treatment resistance, and limit fat gain during chemotherapy.
Recruiting
1 award
Phase 2
Tagraxofusp
for Blood Cancers
Tagraxofusp is a protein-drug conjugate consisting of a diphtheria toxin redirected to target CD123 has been approved for treatment in pediatric and adult patients with blastic plasmacytoid dendritic cell neoplasm (BPDCN). This trial aims to examine the safety of this novel agent in pediatric patients with relapsed/refractory hematologic malignancies. The mechanism by which tagraxofusp kills cells is distinct from that of conventional chemotherapy. Tagraxofusp directly targets CD123 that is present on tumor cells, but is expressed at lower or levels or absent on normal hematopoietic stem cells. Tagraxofusp also utilizes a payload that is not cell cycle dependent, making it effective against both highly proliferative tumor cells and also quiescent tumor cells. The rationale for clinical development of tagraxofusp for pediatric patients with hematologic malignancies is based on the ubiquitous and high expression of CD123 on many of these diseases, as well as the highly potent preclinical activity and robust clinical responsiveness in adults observed to date. This trial includes two parts: a monotherapy phase and a combination chemotherapy phase. This design will provide further monotherapy safety data and confirm the FDA approved pediatric dose, as well as provide safety data when combined with chemotherapy. The goal of this study is to improve survival rates in children and young adults with relapsed hematological malignancies, determine the recommended phase 2 dose (RP2D) of tagraxofusp given alone and in combination with chemotherapy, as well as to describe the toxicities, pharmacokinetics, and pharmacodynamic properties of tagraxofusp in pediatric patients. About 54 children and young adults will participate in this study. Patients with Down syndrome will be included in part 1 of the study.
Recruiting
1 award
Phase 1
More about Melinda Pauly, MD
Clinical Trial Related
9 years of experience running clinical trials · Led 10 trials as a Principal Investigator · 3 Active Clinical Trials
Treatments Melinda Pauly, MD has experience with
- Matched Targeted Therapy
- Marqibo
- IDEAL2 Intervention
- Tagraxofusp
- Quality-of-Life Assessment
- Biospecimen Collection
Breakdown of trials Melinda Pauly, MD has run
Acute Myeloid Leukemia
Leukemia
Acute Lymphoblastic Leukemia
Lymphoblastic Lymphoma
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Frequently asked questions
Do I need insurance to participate in a trial?
Almost all clinical trials will cover the cost of the ‘trial drug’ — so no insurance is required for this. For trials where this trial drug is given alongside an already-approved medication, there may be a cost (which your insurance would normally cover).
What does Melinda Pauly, MD specialize in?
Melinda Pauly, MD focuses on Acute Myeloid Leukemia and Leukemia. In particular, much of their work with Acute Myeloid Leukemia has involved CD123 positive patients, or patients who are KMT2A positive.
Is Melinda Pauly, MD currently recruiting for clinical trials?
Yes, Melinda Pauly, MD is currently recruiting for 3 clinical trials in Atlanta Georgia. If you're interested in participating, you should apply.
Are there any treatments that Melinda Pauly, MD has studied deeply?
Yes, Melinda Pauly, MD has studied treatments such as Matched Targeted Therapy, Marqibo, IDEAL2 Intervention.
What is the best way to schedule an appointment with Melinda Pauly, MD?
Apply for one of the trials that Melinda Pauly, MD is conducting.
What is the office address of Melinda Pauly, MD?
The office of Melinda Pauly, MD is located at: Children's Healthcare of Atlanta, Atlanta, Georgia 30322 United States. This is the address for their practice at the Children's Healthcare of Atlanta.
Is there any support for travel costs?
The coverage of travel expenses can vary greatly between different clinical trials. Please see more financial detail in the trials you’re interested to apply.
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