Matthew T Campbell | MD Anderson Cancer ...

Dr. Matthew Campbell, MD

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UT Southwestern/Simmons Cancer Center-Dallas

Studies Bladder Cancer
Studies Rhabdomyosarcoma
19 reported clinical trials
36 drugs studied

Area of expertise

1

Bladder Cancer

Matthew Campbell, MD has run 5 trials for Bladder Cancer. Some of their research focus areas include:

Stage III
HER2 positive
Stage IV
2

Rhabdomyosarcoma

Matthew Campbell, MD has run 5 trials for Rhabdomyosarcoma. Some of their research focus areas include:

PD-L1 positive
Stage IV
FOXO1 fusion negative

Affiliated Hospitals

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M D Anderson Cancer Center

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UT Southwestern/Simmons Cancer Center-Dallas

Clinical Trials Matthew Campbell, MD is currently running

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Digoxin

for Medulloblastoma

The purpose of this study is to evaluate the efficacy of digoxin in treating relapsed non-SHH, non-WNT medulloblastoma in pediatric and young adult patients.

Recruiting

1 award

Phase 2

9 criteria

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NK Cells + Chemotherapy

for Sarcoma

The purpose of this study is to determine if the addition of infusions of a type of immune cell called a "natural killer", or NK cell to the sarcoma chemotherapy regimen GEM/DOX (gemcitabine and docetaxel) can improve outcomes in people with childhood sarcomas that have relapsed or not responded to prior therapies. The goals of this study are: * To determine the safety and efficacy of the addition of adoptive transfer of universal donor, TGFβ imprinted (TGFβi), expanded NK cells to the pediatric sarcoma salvage chemotherapeutic regimen gemcitabine/docetaxel (GEM/DOX) for treatment of relapsed and refractory pediatric sarcomas To determine the 6-month progression free survival achieved with this treatment in patients within cohorts of relapsed or refractory osteosarcoma, Ewing sarcoma, rhabdomyosarcoma and non-rhabdomyosarcoma soft tissue sarcoma. * To identify toxicities related to treatment with GEM/DOX + TGFβi expanded NK cells Participants will receive study drugs that include chemotherapy and NK cells in cycles; each cycle is 21 days long and you can receive up to 8 cycles. * Gemcitabine (GEM): via IV on Days 1 and 8 * Docetaxel (DOX): via IV on Day 8 * Prophylactic dexamethasone: Day 7-9 to prevent fluid retention and hypersensitivity reaction * Peg-filgrastim (PEG-GCSF) or biosimilar: Day 9 to help your white blood cell recover and allow more chemotherapy to be given * TGFβi NK cells: via IV on Day 12

Recruiting

1 award

Phase 1 & 2

More about Matthew Campbell, MD

Clinical Trial Related

4 years of experience running clinical trials · Led 19 trials as a Principal Investigator · 5 Active Clinical Trials

Treatments Matthew Campbell, MD has experience with

  • Cyclophosphamide
  • Dactinomycin
  • Cisplatin
  • Doxorubicin Hydrochloride
  • Methotrexate
  • Cabozantinib

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