Dr. Mark I Boulos, MD, MSc
Claim this profileSunnybrook Health Sciences Centre
Affiliated Hospitals
Sunnybrook Health Sciences Centre
Dr. Mark I. Boulos - Sunnybrook Health Sciences Centre
Clinical Trials Mark I Boulos, MD, MSc is currently running
Home Sleep Apnea Testing
for Cognitive Impairment
Obstructive sleep apnea (OSA), which causes abnormal pauses in breathing during sleep, is common in patients with vascular cognitive impairment (VCI) and Alzheimer's disease (AD), and exacerbates the cognitive deficits seen in these conditions. OSA is typically treated with continuous positive airway pressure (CPAP), which has been shown to improve cognition in VCI and slow cognitive decline in AD. Despite the need to identify OSA in patients with VCI/AD, these patients often do not undergo testing for OSA. One major barrier is that in-laboratory polysomnography (iPSG), the current standard for diagnosing OSA, is inconvenient for patients with VCI/AD who may be reliant on others for care or require familiar sleep environments. A convenient and cheaper alternative to iPSG is home sleep apnea testing (HSAT), which has been validated against iPSG to diagnose OSA and has proven feasible for use in VCI/AD. Our primary objective is to determine whether the use of HSAT is superior to iPSG in terms of the proportion of patients who complete sleep testing by 6 months post-randomization. We will also investigate cost-effectiveness, patient satisfaction, proportion of patients treated with CPAP, changes in cognition, mood, sleep-related and functional outcomes between HSAT and iPSG at 6 months.
Recruiting
1 award
N/A
4 criteria
Genetic Testing
for Stroke Treatment
Stroke is an important cause of death, disability, and memory problems in adults. The build-up of plaque in arteries inside the brain is known as "intracranial atherosclerotic disease" or "ICAD" for short, and can reduce blood flow in the brain. Clopidogrel is a medicine used to prevent strokes because it stops blood from clotting. However, there are some people who do not get as much benefit from Clopidogrel because of differences in their genes; they have a variation in a certain gene and their body is not able to properly process Clopidogrel. Another medication called Ticagrelor can benefit people who have this genetic variation. The study investigators will randomize patients who have had a stroke due to ICAD to receive genetic testing, or standard of care. The standard-of-care group will take Clopidogrel for 90 days. The genetic testing group will complete a genetic test to see if they can properly process Clopidogrel. Depending on the results of the genetic test, patients will either take Clopidogrel or Ticagrelor for 90 days. All patients will have a brain scan at baseline and 90 days to see if they had any new strokes. Patients will also complete tests and questionnaires about function and memory at baseline and 90 days. This study will be one of the first to see if it is feasible and safe to use genetic testing to help choose medications for patients who have had a stroke. This will help the study investigators design a larger study that can test if genetic testing in stroke patients reduces future stroke risk and improves health outcomes.
Recruiting
1 award
N/A
4 criteria
More about Mark I Boulos, MD, MSc
Clinical Trial Related
3 years of experience running clinical trials · Led 5 trials as a Principal Investigator · 2 Active Clinical Trials
Treatments Mark I Boulos, MD, MSc has experience with
- Home Sleep Apnea Test
- In-laboratory Polysomnography
- Oropharyngeal Exercises
- Sham Exercises
- Clopidogrel
- Ticagrelor
Breakdown of trials Mark I Boulos, MD, MSc has run
Obstructive Sleep Apnea
Vascular Dementia
Alzheimer's Disease
Other Doctors you might be interested in
Frequently asked questions
Do I need insurance to participate in a trial?
Almost all clinical trials will cover the cost of the ‘trial drug’ — so no insurance is required for this. For trials where this trial drug is given alongside an already-approved medication, there may be a cost (which your insurance would normally cover).
What does Mark I Boulos, MD, MSc specialize in?
Mark I Boulos, MD, MSc focuses on Obstructive Sleep Apnea and Stroke. In particular, much of their work with Obstructive Sleep Apnea has involved treating patients, or patients who are undergoing treatment.
Is Mark I Boulos, MD, MSc currently recruiting for clinical trials?
Yes, Mark I Boulos, MD, MSc is currently recruiting for 2 clinical trials in Toronto Ontario. If you're interested in participating, you should apply.
Are there any treatments that Mark I Boulos, MD, MSc has studied deeply?
Yes, Mark I Boulos, MD, MSc has studied treatments such as Home Sleep Apnea Test, In-laboratory polysomnography, Oropharyngeal Exercises.
What is the best way to schedule an appointment with Mark I Boulos, MD, MSc?
Apply for one of the trials that Mark I Boulos, MD, MSc is conducting.
What is the office address of Mark I Boulos, MD, MSc?
The office of Mark I Boulos, MD, MSc is located at: Sunnybrook Health Sciences Centre, Toronto, Ontario M4N3M5 Canada. This is the address for their practice at the Sunnybrook Health Sciences Centre.
Is there any support for travel costs?
The coverage of travel expenses can vary greatly between different clinical trials. Please see more financial detail in the trials you’re interested to apply.
Unbiased Results
We believe in providing patients with all the options.
Your Data Stays Your Data
We only share your information with the clinical trials you're trying to access.
Verified Trials Only
All of our trials are run by licensed doctors, researchers, and healthcare companies.