Tenner, MD | Nebraska Medicine Omaha, NE

Dr. Laura L. Tenner

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Nebraska Medicine-Bellevue

Studies Colorectal Cancer
Studies Colon Cancer
7 reported clinical trials
17 drugs studied

Area of expertise

1

Colorectal Cancer

Laura L. Tenner has run 2 trials for Colorectal Cancer. Some of their research focus areas include:

Stage IV
dMMR positive
MSI-H positive
2

Colon Cancer

Laura L. Tenner has run 2 trials for Colon Cancer. Some of their research focus areas include:

Stage IV
dMMR positive
MSI-H positive

Affiliated Hospitals

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Nebraska Medicine-Bellevue

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Nebraska Medicine-Village Pointe

Clinical Trials Laura L. Tenner is currently running

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Nivolumab + Standard Treatment

for Stomach and Esophageal Cancer

This phase II/III trial compares the addition of nivolumab to the usual treatment of paclitaxel and ramucirumab to paclitaxel and ramucirumab alone in treating patients with gastric or esophageal adenocarcinoma that may have spread from where it first started to nearby tissue, lymph nodes, or distant parts of the body (advanced). A monoclonal antibody is a type of protein that can bind to certain targets in the body, such as molecules that cause the body to make an immune response (antigens). Immunotherapy with monoclonal antibodies, such as nivolumab, may help the body's immune system attack the cancer, and may interfere with the ability of tumor cells to grow and spread. Ramucirumab is a monoclonal antibody that may prevent the growth of new blood vessels that tumors need to grow. Paclitaxel is in a class of medications called antimicrotubule agents. It stops cancer cells from growing and dividing and may kill them. Adding nivolumab to ramucirumab and paclitaxel may work better to treat patients with advanced stomach or esophageal cancer.

Recruiting

1 award

Phase 2 & 3

20 criteria

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Ablative Therapy + Systemic Therapy

for Colorectal Cancer

This phase III trial compares the addition of total ablative therapy to the usual systemic therapy versus the usual systemic therapy alone in treating patients with advanced colorectal cancer that has spread to up to 4 body sites (limited metastatic). The usual approach for patients who are not participating in a study is treatment with intravenous (through a vein) and/or oral medications (systemic therapy) to help stop the cancer sites from getting larger and the spread of the cancer to additional body sites. The ablative local therapy will consist of any combination of very focused, intensive radiotherapy called stereotactic ablative radiotherapy (SABR), surgical resection, or microwave ablation, which is a procedure where a needle is temporarily inserted in the tumor and heat is used to destroy the cancer cells. The addition of ablative local therapy to the usual approach of systemic therapy could be more effective than usual chemotherapy alone by increasing the life of patients with limited metastatic colorectal cancer.

Recruiting

2 awards

Phase 2

More about Laura L. Tenner

Clinical Trial Related

2 years of experience running clinical trials · Led 7 trials as a Principal Investigator · 3 Active Clinical Trials

Treatments Laura L. Tenner has experience with

  • Capecitabine
  • Carboplatin
  • Cisplatin
  • Temozolomide
  • Nivolumab
  • Dostarlimab

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