Christopher L. Moertel | Medical School

Dr. Christopher Moertel

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University of Minnesota/Masonic Cancer Center

Studies Neurofibromatosis
Studies Brain Tumor
15 reported clinical trials
24 drugs studied

Area of expertise

1

Neurofibromatosis

Christopher Moertel has run 8 trials for Neurofibromatosis. Some of their research focus areas include:

NF1 positive
NF2 positive
Stage IV
2

Brain Tumor

Christopher Moertel has run 4 trials for Brain Tumor. Some of their research focus areas include:

Stage IV
NF1 positive
BRAF negative

Affiliated Hospitals

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University Of Minnesota/Masonic Cancer Center

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University Of Minnesota

Clinical Trials Christopher Moertel is currently running

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Selumetinib vs. Chemotherapy

for Brain Cancer

This trial is comparing a new drug, selumetinib, with standard chemotherapy to treat patients with a specific type of brain tumor. The patients do not have a certain genetic mutation and are not affected by a genetic disorder. Selumetinib works by blocking enzymes needed for tumor growth, while the standard drugs kill or stop tumor cells from dividing.

Recruiting

2 awards

Phase 3

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Registry

for Peripheral Nerve Sheath Tumor

First, the investigators plan to use a retrospective analysis to determine the clinical landscape of neurofibromatosis (NF)1-associated malignant peripheral nerve sheath tumor (MPNST) and precursor lesions (e.g., atypical or nodular plexiform neurofibromas). A worldwide database will be established, collecting, in a standardized manner, histologic, immunohistochemical, molecular, radiographic, treatment, and related clinical data from centers worldwide with expertise in these NF1-related cancers. Although retrospective in nature, the resulting data from this registry may reveal previously unanticipated patterns, similar to the INFACT effort outcome. This registry would then allow the acquisition of data associated with MPNST biospecimens collected under associated banks (frozen or paraffin-embedded, germline (or normal tissue DNA) samples, and any previously somatic whole-exome or whole-genome sequencing data for aggregate analyses). Second, the investigators plan to co-register patients to institutional banks in order to prospectively collect MPNST samples for analysis. These patients will be consented in order to collect the above information and for banking of tumor tissue and future studies that include genomic characterization of the tumors.

Recruiting

1 award

N/A

1 criteria

More about Christopher Moertel

Clinical Trial Related

6 years of experience running clinical trials · Led 15 trials as a Principal Investigator · 3 Active Clinical Trials

Treatments Christopher Moertel has experience with

  • Selumetinib
  • Radiation Therapy
  • Mirdametinib (PD-0325901)
  • Curcumin
  • High Phenolic Extra Virgin Olive Oil (HP-EVOO)
  • Placebo

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