Dr. Carla B. Golden
Claim this profileUCSF Benioff Children's Hospital Oakland
Area of expertise
Cancer
Carla B. Golden has run 21 trials for Cancer. Some of their research focus areas include:
Neuroblastoma
Carla B. Golden has run 15 trials for Neuroblastoma. Some of their research focus areas include:
Affiliated Hospitals
UCSF Benioff Children's Hospital Oakland
Children's Hospital And Research Center At Oakland
Clinical Trials Carla B. Golden is currently running
Inotuzumab Ozogamicin
for Acute Lymphoblastic Leukemia
This phase III trial studies whether inotuzumab ozogamicin added to post-induction chemotherapy and immunotherapy (chemo-immunotherapy) for patients with High-Risk B-cell Acute Lymphoblastic Leukemia (B-ALL) improves outcomes. Inotuzumab ozogamicin is a monoclonal antibody, which is a type of protein that can bind to certain targets on the surface of cells. Inotuzumab ozogamicin is a monoclonal antibody that is linked to a type of chemotherapy called calicheamicin. Inotuzumab attaches to cancer cells by binding to the CD22 protein on the surface of the cancer cell and delivering calicheamicin inside the cells to kill them. Other drugs used in the chemotherapy regimen, such as cyclophosphamide, cytarabine, dexamethasone, doxorubicin, daunorubicin, methotrexate, leucovorin, mercaptopurine, prednisone, thioguanine, vincristine, and pegaspargase or calaspargase pegol work in different ways to stop the growth of cancer cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. Blinatumomab is a specialized type of monoclonal antibody known as a bispecific T-cell engager (BiTE). It works by simultaneously binding to CD19 on cancer cells and CD3 on normal immune cells, bringing them together to destroy leukemia cells. Blinatumomab is a standard part of chemo-immunotherapy treatment for B-ALL. This trial also studies the outcomes of patients with mixed phenotype acute leukemia (MPAL), and B-lymphoblastic lymphoma (B-LLy) when treated with ALL therapy without inotuzumab ozogamicin or blinatumomab. The overall goal of this study is to understand if adding inotuzumab ozogamicin to standard of care chemo-immunotherapy maintains or improves outcomes in High Risk B-cell Acute Lymphoblastic Leukemia (HR B-ALL). The first part of the study includes the first phase of therapy: Induction. This part will collect information on the leukemia, as well as the effects of the initial treatment, to classify patients into post-induction treatment groups. On the second part of this study, patients with HR B-ALL will receive the remainder of the chemotherapy cycles (consolidation, blinatumomab block 1, interim maintenance 1, blinatumomab block 2, delayed intensification, interim maintenance 2, maintenance), with some patients randomized to receive inotuzumab. The patients that receive inotuzumab will not receive part of consolidation or part of delayed intensification. Other aims of this study include evaluating 1) side effects of treatment using patient-reported outcomes and health-related quality of life, 2) the best ways to help patients adhere to oral chemotherapy regimens, 3) the relationship between levels of inotuzumab ozogamicin in the blood and side effects, 4) the impact of chemo-immunotherapy on the immune system and risk of infection, and 5) the impact of social determinants of health on outcomes. Finally, this study will be the first to track the outcomes of subjects with disseminated B-cell Lymphoblastic Leukemia (B-LLy) or Mixed Phenotype Acute Leukemia (MPAL) when treated with B-ALL chemotherapy.
Recruiting
2 awards
Phase 3
DAY101
for Langerhans Cell Histiocytosis
This trial tests the safety and effectiveness of tovorafenib (DAY101) in children and young adults with Langerhans cell histiocytosis that is worsening, has returned, or does not respond to other treatments. Tovorafenib is taken orally and works by blocking enzymes needed for cancer cell growth. The study aims to find the best dose and observe the response and side effects over time.
Recruiting
1 award
Phase 2
28 criteria
More about Carla B. Golden
Clinical Trial Related
9 years of experience running clinical trials · Led 43 trials as a Principal Investigator · 8 Active Clinical Trials
Treatments Carla B. Golden has experience with
- Cyclophosphamide
- Laboratory Biomarker Analysis
- Etoposide
- Cytology Specimen Collection Procedure
- Methotrexate
- Vincristine Sulfate
Breakdown of trials Carla B. Golden has run
Cancer
Neuroblastoma
Rhabdomyosarcoma
Langerhans Cell Histiocytosis
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Frequently asked questions
Do I need insurance to participate in a trial?
Almost all clinical trials will cover the cost of the ‘trial drug’ — so no insurance is required for this. For trials where this trial drug is given alongside an already-approved medication, there may be a cost (which your insurance would normally cover).
What does Carla B. Golden specialize in?
Carla B. Golden focuses on Cancer and Neuroblastoma. In particular, much of their work with Cancer has involved Stage I patients, or patients who are Stage IV.
Is Carla B. Golden currently recruiting for clinical trials?
Yes, Carla B. Golden is currently recruiting for 8 clinical trials in Oakland California. If you're interested in participating, you should apply.
Are there any treatments that Carla B. Golden has studied deeply?
Yes, Carla B. Golden has studied treatments such as Cyclophosphamide, Laboratory Biomarker Analysis, Etoposide.
What is the best way to schedule an appointment with Carla B. Golden?
Apply for one of the trials that Carla B. Golden is conducting.
What is the office address of Carla B. Golden?
The office of Carla B. Golden is located at: UCSF Benioff Children's Hospital Oakland, Oakland, California 94609 United States. This is the address for their practice at the UCSF Benioff Children's Hospital Oakland.
Is there any support for travel costs?
The coverage of travel expenses can vary greatly between different clinical trials. Please see more financial detail in the trials you’re interested to apply.
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