Dr. Antonio Abbate, MD
Claim this profileVirginia Commonwealth University
Affiliated Hospitals
Virginia Commonwealth University
University Of Virginia
Clinical Trials Antonio Abbate, MD is currently running
Steroids
for Myocarditis
This trial tests if giving high doses of a steroid medication can help patients with severe heart inflammation recover better. The treatment targets those with serious heart issues, aiming to reduce inflammation and improve heart function.
Recruiting
1 award
Phase 3
8 criteria
Colchicine
for Heart Failure
This is a double blind, placebo-controlled pilot trial randomizing patients admitted to the hospital with acutely decompensated heart failure (ADHF) and inflammation to receive either colchicine or matching placebo. Upon enrollment, patients will be randomized 1:1 to receive either the experimental drug (Colchicine) or matching placebo. The regimen in the active arm will consist of 14 days of Colchicine 0.6 mg bid followed by 76±14 days of Colchicine 0.6 mg once per day. Placebo regimen will be analogous, with one pill bid for 14 days followed by one pill once per day for 76 days. Dose reduction for patients with Stage III chronic kidney disease is allowed as detailed in the protocol. At the same time, dose reduction can also be elected in case of GI symptoms. The study team will transiently stop the experimental medication in case of acute kidney injury (AKI), defined per Kidney Disease Improving Global Outcomes (KDIGO) Stage I, as specified in the protocol. These patients will continue with their standard of care for the management of heart failure which consists of a combination of medications that relieve congestion, normalize blood pressure and heart rate, and block the effects of hormones on the heart. The proposed treatment will be in addition to standard of care. No standard of care medications will be withheld. While inflammation is a known risk factor in heart failure, there are no standard anti-inflammatory drugs used in patients with heart failure, as the benefit is not established. The study team will study colchicine, an anti-inflammatory drug, as compares with placebo. Blood will be obtained from the patients in order to measure hsCRP and IL-6. Blood samples will be collected at baseline, 24±6h, 48±6h and 72±6h after treatment initiation, and subsequently at 14±7 days and at study closure. The first four blood samples will be obtained while the subject is still admitted to the hospital. The blood sample at 14±7 days will be obtained during an outpatient encounter. A study closure visit with clinical assessment and experimental drug collection for capsule counting to assess compliance will be conducted at 90±14; the final blood sample will be collected at that time.
Recruiting
2 awards
Phase 4
More about Antonio Abbate, MD
Clinical Trial Related
4 years of experience running clinical trials · Led 7 trials as a Principal Investigator · 2 Active Clinical Trials
Treatments Antonio Abbate, MD has experience with
- Placebo
- Anakinra
- RPH-104
- Atibuclimab
- Colchicine
- Methylprednisolone
Breakdown of trials Antonio Abbate, MD has run
Heart Failure
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Frequently asked questions
Do I need insurance to participate in a trial?
Almost all clinical trials will cover the cost of the ‘trial drug’ — so no insurance is required for this. For trials where this trial drug is given alongside an already-approved medication, there may be a cost (which your insurance would normally cover).
What does Antonio Abbate, MD specialize in?
Antonio Abbate, MD focuses on Heart Failure and Inflammation. In particular, much of their work with Heart Failure has involved treating patients, or patients who are undergoing treatment.
Is Antonio Abbate, MD currently recruiting for clinical trials?
Yes, Antonio Abbate, MD is currently recruiting for 2 clinical trials in Richmond Virginia. If you're interested in participating, you should apply.
Are there any treatments that Antonio Abbate, MD has studied deeply?
Yes, Antonio Abbate, MD has studied treatments such as Placebo, Anakinra, RPH-104.
What is the best way to schedule an appointment with Antonio Abbate, MD?
Apply for one of the trials that Antonio Abbate, MD is conducting.
What is the office address of Antonio Abbate, MD?
The office of Antonio Abbate, MD is located at: Virginia Commonwealth University, Richmond, Virginia 23298 United States. This is the address for their practice at the Virginia Commonwealth University.
Is there any support for travel costs?
The coverage of travel expenses can vary greatly between different clinical trials. Please see more financial detail in the trials you’re interested to apply.
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