University of Mississippi Medical Center

Dr. Anderson (Andy) B. Collier

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University of Mississippi Medical Center

Expert in Cancer
Expert in Neuroblastoma
52 reported clinical trials
102 drugs studied

About Anderson (Andy) B. Collier

Education:

  • Earned an MD (Doctor of Medicine) from an unspecified institution.

Experience:

  • Serves as the Director of Mississippi's only pediatric cancer and blood disorders center at the Children's of Mississippi Center for Cancer and Blood Disorders.
  • Specializes in treating a wide range of childhood cancers and blood disorders.
  • Actively involved in clinical trials for innovative treatments for cancer and sickle cell anemia.
  • Engages in research on targeted agents, immunotherapies, and gene therapy for cancer and blood disorders.

Area of expertise

1

Cancer

Global Leader

Anderson (Andy) B. Collier has run 19 trials for Cancer. Some of their research focus areas include:

Stage I
Stage IV
Stage II
2

Neuroblastoma

Global Leader

Anderson (Andy) B. Collier has run 16 trials for Neuroblastoma. Some of their research focus areas include:

MYC positive
Stage IV
MYC negative

Affiliated Hospitals

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University Of Mississippi Medical Center

Clinical Trials Anderson (Andy) B. Collier is currently running

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Selumetinib vs. Chemotherapy

for Brain Cancer

This trial is comparing a new drug, selumetinib, with standard chemotherapy to treat patients with a specific type of brain tumor. The patients do not have a certain genetic mutation and are not affected by a genetic disorder. Selumetinib works by blocking enzymes needed for tumor growth, while the standard drugs kill or stop tumor cells from dividing.

Recruiting

2 awards

Phase 3

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Inotuzumab Ozogamicin

for Acute Lymphoblastic Leukemia

This phase III trial studies whether inotuzumab ozogamicin added to post-induction chemotherapy and immunotherapy (chemo-immunotherapy) for patients with High-Risk B-cell Acute Lymphoblastic Leukemia (B-ALL) improves outcomes. Inotuzumab ozogamicin is a monoclonal antibody, which is a type of protein that can bind to certain targets on the surface of cells. Inotuzumab ozogamicin is a monoclonal antibody that is linked to a type of chemotherapy called calicheamicin. Inotuzumab attaches to cancer cells by binding to the CD22 protein on the surface of the cancer cell and delivering calicheamicin inside the cells to kill them. Other drugs used in the chemotherapy regimen, such as cyclophosphamide, cytarabine, dexamethasone, doxorubicin, daunorubicin, methotrexate, leucovorin, mercaptopurine, prednisone, thioguanine, vincristine, and pegaspargase or calaspargase pegol work in different ways to stop the growth of cancer cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. Blinatumomab is a specialized type of monoclonal antibody known as a bispecific T-cell engager (BiTE). It works by simultaneously binding to CD19 on cancer cells and CD3 on normal immune cells, bringing them together to destroy leukemia cells. Blinatumomab is a standard part of chemo-immunotherapy treatment for B-ALL. This trial also studies the outcomes of patients with mixed phenotype acute leukemia (MPAL), and B-lymphoblastic lymphoma (B-LLy) when treated with ALL therapy without inotuzumab ozogamicin or blinatumomab. The overall goal of this study is to understand if adding inotuzumab ozogamicin to standard of care chemo-immunotherapy maintains or improves outcomes in High Risk B-cell Acute Lymphoblastic Leukemia (HR B-ALL). The first part of the study includes the first phase of therapy: Induction. This part will collect information on the leukemia, as well as the effects of the initial treatment, to classify patients into post-induction treatment groups. On the second part of this study, patients with HR B-ALL will receive the remainder of the chemotherapy cycles (consolidation, blinatumomab block 1, interim maintenance 1, blinatumomab block 2, delayed intensification, interim maintenance 2, maintenance), with some patients randomized to receive inotuzumab. The patients that receive inotuzumab will not receive part of consolidation or part of delayed intensification. Other aims of this study include evaluating 1) side effects of treatment using patient-reported outcomes and health-related quality of life, 2) the best ways to help patients adhere to oral chemotherapy regimens, 3) the relationship between levels of inotuzumab ozogamicin in the blood and side effects, 4) the impact of chemo-immunotherapy on the immune system and risk of infection, and 5) the impact of social determinants of health on outcomes. Finally, this study will be the first to track the outcomes of subjects with disseminated B-cell Lymphoblastic Leukemia (B-LLy) or Mixed Phenotype Acute Leukemia (MPAL) when treated with B-ALL chemotherapy.

Recruiting

2 awards

Phase 3

More about Anderson (Andy) B. Collier

Clinical Trial Related

9 years of experience running clinical trials · Led 52 trials as a Principal Investigator · 15 Active Clinical Trials

Treatments Anderson (Andy) B. Collier has experience with

  • Cyclophosphamide
  • Radiation Therapy
  • Etoposide
  • Vincristine Sulfate
  • Carboplatin
  • Doxorubicin Hydrochloride

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