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We started Power when my dad was diagnosed with multiple myeloma, and I struggled to help him access the latest immunotherapy. Hopefully Power makes it simpler for you to explore promising new treatments, during what is probably a difficult time.

Bask
Bask GillCEO at Power
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      Why We Started Power

      We started Power when my dad was diagnosed with multiple myeloma, and I struggled to help him access the latest immunotherapy. Hopefully Power makes it simpler for you to explore promising new treatments, during what is probably a difficult time.

      Bask
      Bask GillCEO at Power
      Learn More About Trials
      How Do Clinical Trials Work?Are Clinical Trials Safe?What Can I Expect During a Clinical Trial?

      26 Tinnitus Trials Near You

      Power is an online platform that helps thousands of Tinnitus patients discover FDA-reviewed trials every day. Every trial we feature meets safety and ethical standards, giving patients an easy way to discover promising new treatments in the research stage.

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      No Placebo
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      Pivotal Trials (Near Approval)
      Breakthrough Medication

      ACEMg for Hearing Loss and Tinnitus

      Ann Arbor, Michigan
      ACEMg (Soundbites) is a neuroprotectant supplement designed to block the initiating biological events in the inner ear leading to inner ear hearing loss, sensorineural hearing loss, SNHL, which accounts for more than 90% of all hearing loss. SNHL is so common it is called hearing loss. There is no cure for SNHL. The 24-week OTIS Study aims to validate findings from the previous two-year real-world study demonstrating ACEMg (Soundbites) preserved or improved auditory function (hearing) for 75.3% of participants who used it daily, with most improvement occurring within six months. The study also aims to assess the potential of ACEMg to relieve tinnitus, hyperacusis, and hearing sensitivity symptoms. These symptoms are often correlated with SNHL; relief from tinnitus, hyperacusis and hearing sensitivity were were not measured in the previous two-year study. The OTIS study aims to answer two questions. First, does the real-world data demonstrate that hearing loss is stabilized or improved at the end of the test among participants with SNHL at the beginning? Second, do participants who self-report tinnitus, hyperacusis, or hearing sensitivity symptoms at the start of their test report reduced symptoms at the end? Participants must be eighteen years of age and older and self-report hearing loss and/or tinnitus. The study is conducted at home using a smartphone app and a web-based assessment and data reporting tool developed for this study. The study is conducted at home using an online hearing test and short surveys on tinnitus and hyperacusis. The tests are completed three times: Baseline tests are taken before participants begin to take ACEMg softgel capsules daily. The Test is repeated at about 11 and 24 weeks. Assessment scores at the beginning of the study will be compared with scores at the end. Participation in the study is free.
      No Placebo Group

      Trial Details

      Trial Status:Recruiting
      Trial Phase:Unphased

      Key Eligibility Criteria

      Disqualifiers:No Tinnitus, No Hearing Loss, Previous ACEMg Use

      200 Participants Needed

      Sound Exposure Monitoring for Hearing Loss

      Ann Arbor, Michigan
      The Apple Hearing Study is a partnership between the University of Michigan and Apple to study sound exposure and its impact on hearing health. This groundbreaking study will advance the understanding of how hearing could be impacted over time by exposure to sound at certain levels. The investigators will measure headphone and environmental sound exposures over time among participants, and determine how these exposures impact hearing and stress levels. US residents who own an iPhone, download the Apple Research app and consent to participate will be randomly assigned to two groups, one with a "Basic" user interface in the Research app, and one with an "Advanced" user interface. Users in the "Advanced" group will receive additional information about their exposures and be given additional surveys and hearing tests based on their music and environmental sound exposures. The study will provide investigators with a better understanding of listening behavior and its overall impact on hearing health. This information will in turn help guide public health policy and prevention programs designed to protect and promote hearing health in the US and globally.
      No Placebo Group

      Trial Details

      Trial Status:Recruiting

      Key Eligibility Criteria

      Disqualifiers:Shared ICloud, Shared IPhone, Others

      300000 Participants Needed

      Etanercept for Tinnitus

      Detroit, Michigan
      This trial tests if Etanercept injections can help adults with noise-induced tinnitus by reducing inflammation. The study aims to see if it can lower tinnitus distress and loudness, and improve hearing.

      Trial Details

      Trial Status:Recruiting
      Trial Phase:Phase 2

      Key Eligibility Criteria

      Disqualifiers:Diabetes, Seizure Disorder, Auto-immune Disease, Others
      Must Not Be Taking:Immunomodulatory Biologics, Cyclophosphamide, Sulfonylureas, Others

      88 Participants Needed

      Curcumin for Tinnitus

      Royal Oak, Michigan
      This trial tests a pill with curcumin and boswellia for people with severe tinnitus due to hearing loss. The pill is designed to reduce ear inflammation and potentially decrease the ringing sound.

      Trial Details

      Trial Status:Active Not Recruiting
      Trial Phase:Unphased

      Key Eligibility Criteria

      Disqualifiers:Pregnancy, Allergy, Other Tinnitus Causes, Others
      Must Not Be Taking:Antidepressants, GABA-inhibitors, Anticoagulants

      110 Participants Needed

      Guided ICBT for Tinnitus

      London, Ontario
      The goal of this randomized controlled trial is to learn if guided Internet-delivered Cognitive Behavioural Therapy can treat tinnitus-related distress and its associated comorbidities such as anxiety, depression, insomnia, and quality of life among adult tinnitus patients in Canada. The main questions it aims to answer are: * Does guided internet-delivered cognitive behavioural therapy for the treatment of tinnitus reduce tinnitus-related distress and tinnitus-associated comorbidities (depression, anxiety, insomnia, quality of life) among adult tinnitus patients aged 18-79 years in Canada from pre-treatment to post-treatment and 3-month follow-up? * Do participants in the personalized ICBT treatment group show worse improvements in patient-reported outcomes from pre-treatment to post-treatment and 3-month follow-up than the standard ICBT control group? The researchers will compare a personalized ICBT program to a standard ICBT program to investigate if participants in the personalized ICBT program will show no worse improvements in patient-reported outcomes from pre-treatment to post-treatment and 3-month follow-up than the active comparator, the standard ICBT program. Participants will: * Receive either a personalized ICBT program or a standard ICBT program delivered over 8 weeks consisting of 21 modules. * Receive guided support of approximately 10-15 minutes per week by video chat or phone from a trained Guide over the 8-week duration of the program. * Complete assessments at baseline, post-intervention, and 3-month follow-up through online REDCap surveys with automatic emails and telephone reminders.
      No Placebo Group

      Trial Details

      Trial Status:Not Yet Recruiting
      Trial Phase:Unphased

      Key Eligibility Criteria

      Disqualifiers:Severe Mental Health, Cognitive Impairments, Others

      82 Participants Needed

      Sound-based Treatment for Tinnitus

      Toronto, Ontario
      The goal of this clinical trial is to assess the effectiveness of a sound-based passive treatment for reducing stress and annoyance induced by tinnitus, and how this therapy may improve tinnitus sufferers' quality of life. The main questions it aims to answer are: • \[question 1: to assess the efficacy of the LUCID/VIBE in managing the tinnitus handicap (measured by the reducing of the annoyance/stress response to tinnitus) contributing to the improvement of the quality of life of people living with tinnitus\] and • \[question 2: assess the efficacy of LUCID/VIBE in providing temporary relief through masking, such that it results in a reduction of the perceived loudness of tinnitus\]. Participants will \[use the VIBE app for 24 minutes a day for a period of 4 weeks. There will be two conditions, a Noise condition (the control condition in which the investigator will administer white noise) and the VIBE condition (the treatment condition). One approach involves broad-band masking with noise (Noise Condition), while the other uses music (LUCID Condition). Implementation of the noise condition will mirror the LUCID condition in terms of ease of access, look, feel, so that one condition does not look less professional than the other. Both conditions will be administered through the same app, and only the sound conditions will differ (white noise vs. LUCID music). All participants will be exposed to both the treatment and control conditions with the order of conditions counter-balanced (i.e., a cross-over design).

      Trial Details

      Trial Status:Recruiting
      Trial Phase:Unphased
      Age:40 - 85

      Key Eligibility Criteria

      Disqualifiers:Age, Pulsatile Tinnitus, Other Treatments, Others

      50 Participants Needed

      Notched Noise Therapy for Tinnitus

      Durham, North Carolina
      This trial uses a special sound therapy to help Veterans with chronic tinnitus. The therapy involves listening to sounds with a specific part removed to help reduce the ringing in the ears. The goal is to find out if this method can effectively lower the loudness of tinnitus and improve overall well-being. This sound therapy has been suggested to be effective for relieving tinnitus.

      Trial Details

      Trial Status:Recruiting
      Trial Phase:Unphased

      Key Eligibility Criteria

      Disqualifiers:Hearing Loss, Meniere's Disease, Others

      108 Participants Needed

      Vagus Auricular Stimulation for Tinnitus

      Saint Louis, Missouri
      This pilot study is a randomized, double-blinded controlled trial of adult participants with chronic, moderate to severe bothersome subjective tinnitus. Participants will be randomly assigned to either an active auricular stimulation device group or a sham-control group.Both groups will also undergo virtual Mindfulness-Based Stress Reduction(MBSR) over 8 weeks to promote tinnitus bother reduction, and general well-being. Outcome measures will be assessed at baseline, end of intervention, and at 1-month post-intervention.

      Trial Details

      Trial Status:Active Not Recruiting
      Trial Phase:Unphased

      Key Eligibility Criteria

      Disqualifiers:Age >70, Pregnancy, Ear Pathology, Others

      40 Participants Needed

      Ebselen for Menière's Disease

      Philadelphia, Pennsylvania
      Study of the safety of open-label SPI-1005 400 mg BID treatment in adults with Meniere's Disease (MD) for 6 or 12 months to support chronic or chronic intermittent use.
      No Placebo Group
      Pivotal Trial (Near Approval)

      Trial Details

      Trial Status:Recruiting
      Trial Phase:Phase 3

      Key Eligibility Criteria

      Disqualifiers:Otosclerosis, Significant Ear Surgery, Others
      Must Not Be Taking:Ototoxic Medications, Systemic Steroids

      200 Participants Needed

      Tinnitus Implant for Tinnitus

      Rochester, Minnesota
      This trial is testing a new device called the Tinnitus Implant System for people with persistent ringing in their ears. The device is surgically implanted and helps reduce the ringing sound. Participants will need to visit the clinic periodically for adjustments and evaluations.
      No Placebo Group

      Trial Details

      Trial Status:Active Not Recruiting
      Trial Phase:Unphased

      Key Eligibility Criteria

      Disqualifiers:Pregnancy, Brain Surgery, Major Head Trauma, Others
      Must Not Be Taking:Antidepressants, Anxiolytics, Antipsychotics

      9 Participants Needed

      Noise Correlations Study for Dyslexia

      Providence, Rhode Island
      A fundamental problem in neuroscience is how the brain computes with noisy neurons. An advantage of population codes is that downstream neurons can pool across multiple neurons to reduce the impact of noise. However, this benefit depends on the noise associated with each neuron being independent. Noise correlations refer to the covariance of noise between pairs of neurons, and such correlations can limit the advantages gained from pooling across large neural populations. Indeed, a large body of theoretical work argues that positive noise correlations between similarly tuned neurons reduce the representational capacity of neural populations and are thus detrimental to neural computation. Despite this apparent disadvantage, such noise correlations are observed across many different brain regions, persist even in well-trained subjects, and are dynamically altered in complex tasks. The investigators have advanced the hypothesis that noise correlations may be a neural mechanism for reducing the dimensionality of learning problems. The viability of this hypothesis has been demonstrated in neural network simulations where noise correlations, when embedded in populations with fixed signal-to-noise ratio, enhance the speed and robustness of learning. Here the investigators aim to empirically test this hypothesis, using a combination of computational modeling, fMRI and pupillometry. Establishing a link between noise correlations and learning would open the door to an investigation into how brains navigate a tradeoff between representational capacity and the speed of learning.
      No Placebo Group

      Trial Details

      Trial Status:Recruiting
      Trial Phase:Unphased

      Key Eligibility Criteria

      Disqualifiers:Claustrophobia, Color Blindness, Stroke, Others
      Must Not Be Taking:Neuroleptics

      40 Participants Needed

      Xeomin Injections for Tinnitus

      Minneapolis, Minnesota
      This trial is testing Xeomin injections to help people with tinnitus, a condition that causes persistent ringing in the ears. Xeomin is a type of botulinum toxin that, when injected into ear muscles, may reduce the ringing by relaxing these muscles. The effectiveness will be measured using a questionnaire. Xeomin has been explored in various studies for its potential to treat tinnitus by relaxing ear muscles.

      Trial Details

      Trial Status:Active Not Recruiting
      Trial Phase:Phase 2

      Key Eligibility Criteria

      Disqualifiers:Hypersensitivity, Infection, Surgery, Psychiatric, Others
      Must Not Be Taking:Botulinum Toxin

      33 Participants Needed

      Lenire Device for Tinnitus

      Minneapolis, Minnesota
      The aim of the proposed study is to investigate the use of resting-state Electroencephalogram (EEG)-Based Brain Entropy (EBDBE) and auditory brainstem responses (ABR) as an objective measure of tinnitus improvement following the use of a bimodal stimulation device in individuals with tinnitus after six weeks of bi-modal stimulation.
      No Placebo Group

      Trial Details

      Trial Status:Recruiting
      Trial Phase:Unphased

      Key Eligibility Criteria

      Disqualifiers:Meniere's, Epilepsy, Psychosis, TMJ, Others
      Must Not Be Taking:Antidepressants, Anticonvulsants, Neuroleptics, Opioids

      24 Participants Needed

      Bimodal Neuromodulation for Tinnitus

      Minneapolis, Minnesota
      The research objective of the proposed usability study is to assess the compliance and acceptance/satisfaction of using a bimodal stimulation device with the modification of the sound stimulus to the participant's tinnitus pitch. In particular, the sound stimulus will not contain the pitch of the tinnitus, which may increase comfort and usability with the device since it will be customized to their tinnitus. Furthermore, virtual follow-up assessments and/or phone calls will be performed, thus significantly reducing the burden and personnel requirements for in-person visits as originally performed with the current clinic process.
      No Placebo Group

      Trial Details

      Trial Status:Active Not Recruiting
      Trial Phase:Unphased

      Key Eligibility Criteria

      Disqualifiers:Meniere's Disease, Hyperacusis, Epilepsy, Schizophrenia, Others
      Must Not Be Taking:Antidepressants, Anticonvulsants, Neuroleptics, Opioids

      20 Participants Needed

      Bimodal Stimulation Device for Tinnitus

      Minneapolis, Minnesota
      The research objective of the proposed usability study is to assess the compliance and acceptance/satisfaction of using a bimodal stimulation device with the ability to self-adjust the sound stimulus presented to the ears via headphones. In particular, the CE marked bimodal stimulation portable device, Lenire, which is developed by Neuromod Devices Limited (Dublin, Ireland) to alleviate the symptoms of chronic subjective tinnitus, is currently configured according to a tinnitus person's audiogram (i.e., hearing threshold profile for different sound frequencies) during fitting in a hearing center. Lenire device is a non-invasive stimulation device that consists of a controller that connects to headphones for sound delivery to the ears and connects to a mouth component that provides gentle electrical stimulation to the tongue surface. Individuals are recommended to use the device for 60 minutes daily (two 30-minute sessions consecutively or at different times of the day) for at least 10 weeks. Lenire is already commercialized across Europe and available by audiologists or hearing technicians in numerous hearing centers for treating tinnitus. It has also been evaluated in two large-scale clinical trials in over 500 tinnitus participants, demonstrating tinnitus benefit and minimal risk with high compliance and satisfaction rates. The primary objective of the proposed usability study is to first assess compliance and satisfaction with the Lenire device that does not require an audiogram for fitting and that can be implemented mostly through virtual visits (except for the first visit). These modifications to the Lenire fitting process will reduce the time and personnel effort required for its implementation, enabling a broader patient population to access bimodal stimulation for tinnitus treatment, including military personnel and those who are not nearby hearing centers for in-person sessions. High compliance and satisfaction rates from this small proof-of concept usability study will then justify and guide a larger clinical study to assess efficacy and performance of this newly implemented Lenire device process.
      No Placebo Group

      Trial Details

      Trial Status:Active Not Recruiting

      Key Eligibility Criteria

      Disqualifiers:Not Listed

      46 Participants Needed

      IV Lidocaine for Tinnitus

      Boston, Massachusetts
      This trial is testing if giving lidocaine through an IV can temporarily reduce tinnitus. It includes patients with and without hearing loss. The goal is to see if lidocaine changes brain activity related to tinnitus. Lidocaine has been studied for its potential to temporarily relieve tinnitus, but its clinical use is limited due to brief effects and side effects.
      No Placebo Group

      Trial Details

      Trial Status:Recruiting
      Trial Phase:Early Phase 1

      Key Eligibility Criteria

      Disqualifiers:Seizure Disorder, Cardiac Arrhythmias, Neurological Disorders, Others
      Must Not Be Taking:Antiarrhythmics, Antibiotics

      40 Participants Needed

      Auditory Mirror Therapy for Tinnitus

      Charlestown, Massachusetts
      This trial tests special earmuffs that switch sounds between ears to help people with chronic tinnitus. The goal is to see if this can reduce their symptoms by changing how their brain processes sounds. Auditory mirror therapy (AMT) involves swapping sounds between ears to reduce tinnitus, similar to mirror box therapy used for phantom limb pain.

      Trial Details

      Trial Status:Active Not Recruiting
      Trial Phase:Unphased

      Key Eligibility Criteria

      Disqualifiers:Hearing Aids, Drug Or Alcohol Use, Neurological Or Psychiatric Illnesses, Balance Or Vestibular Symptoms, Others

      50 Participants Needed

      Osteopathic Manipulative Treatment for Throwing Performance

      Hattiesburg, Mississippi
      To investigate the impact of manual medicine on key aspects of the kinetic chain on measures of performance in baseball players.
      No Placebo Group

      Trial Details

      Trial Status:Enrolling By Invitation
      Trial Phase:Unphased
      Sex:Male

      Key Eligibility Criteria

      Disqualifiers:Injuries Preventing Practice, Others

      30 Participants Needed

      Therapeutic Hypothermia for Tinnitus

      Miami, Florida
      The goal of this interventional clinical study is to establish mild therapeutic hypothermia, delivered non-invasively to the structures of the inner ear, as a safe and repeatable therapeutic method for symptomatic relief of tinnitus. The study will assess both objective and subjective measures to address two main aims: 1. Ascertain the benefits of mild therapeutic hypothermia for symptomatic relief of chronic tinnitus in participants using the ReBound hypothermia device. 2. Ascertain the benefits of mild therapeutic hypothermia for symptom management in chronic tinnitus participants over six months using the ReBound device. Participants will wear the ReBound hypothermia device for 30 minutes in a single session. Researchers will compare results from those receiving the therapy to those from a control group (sham therapy). Participants will also use the device in-home for 6 months and monitor their symptoms with online surveys.

      Trial Details

      Trial Status:Not Yet Recruiting
      Trial Phase:Unphased

      Key Eligibility Criteria

      Disqualifiers:Severe Anxiety, Catastrophic Tinnitus, Otologic Pathologies, Others

      40 Participants Needed

      Cognitive Processing Therapy + CBT-t for Post-Traumatic Stress Disorder

      San Antonio, Texas
      In this study, researchers are examining the best sequence of interventions for posttraumatic stress disorder (PTSD) and tinnitus. Participants will either receive psychotherapy for PTSD first (Cognitive Processing Therapy; CPT), followed by treatment for tinnitus (Cognitive Behavioral Therapy for Tinnitus; CBT-t); or vice-versa. We also aim to identify changes in brain functioning after receiving therapy.
      No Placebo Group

      Trial Details

      Trial Status:Recruiting
      Trial Phase:Unphased

      Key Eligibility Criteria

      Disqualifiers:Severe Hearing Loss, Suicidal Ideation, Substance Use, Others

      160 Participants Needed

      Why Other Patients Applied

      "I've tried several different SSRIs over the past 23 years with no luck. Some of these new treatments seem interesting... haven't tried anything like them before. I really hope that one could work."

      ZS
      Depression PatientAge: 51

      "My orthopedist recommended a half replacement of my right knee. I have had both hips replaced. Currently have arthritis in knee, shoulder, and thumb. I want to avoid surgery, and I'm open-minded about trying a trial before using surgery as a last resort."

      HZ
      Arthritis PatientAge: 78

      "I've been struggling with ADHD and anxiety since I was 9 years old. I'm currently 30. I really don't like how numb the medications make me feel. And especially now, that I've lost my grandma and my aunt 8 days apart, my anxiety has been even worse. So I'm trying to find something new."

      FF
      ADHD PatientAge: 31

      "I have dealt with voice and vocal fold issues related to paralysis for over 12 years. This problem has negatively impacted virtually every facet of my life. I am an otherwise healthy 48 year old married father of 3 living. My youngest daughter is 12 and has never heard my real voice. I am now having breathing issues related to the paralysis as well as trouble swallowing some liquids. In my research I have seen some recent trials focused on helping people like me."

      AG
      Paralysis PatientAge: 50

      "As a healthy volunteer, I like to participate in as many trials as I'm able to. It's a good way to help research and earn money."

      IZ
      Healthy Volunteer PatientAge: 38
      Match to a Tinnitus Trial

      Virtual Reality Mindfulness for Tinnitus and Misophonia

      Aurora, Colorado
      Children with "bothersome" tinnitus and misophonia have elevated anxiety and depression symptoms. The mainstay therapy for adults and children with these disorders is cognitive behavioral therapy (CBT). CBT resources are expensive and scarce for the pediatric population. Immersive virtual reality (IVR) has been shown in the adult population to be a proxy for CBT for several mental health disorders. There is sufficient published evidence that IVR is useful in treating adults with anxiety and depression disorders. However, the evidence in children in treating either anxiety and depression symptoms or disorder is scant. Our group views IVR application as a promising medical device to decrease anxiety and depression scores in children with tinnitus and misophonia disorders. This is a randomized placebo control (single-blinded to the study subjects) study in which there will be a 2:1 ratio between the experimental and placebo subjects, receiving either active IVR or placebo exposure. A total of 30 subjects with 20 experimental (10 tinnitus, 10 misophonia subjects) and 10 placebo (5 tinnitus and 5 misophonia subjects) will enroll in this randomized clinical trial. Assessment of change of quality of life, anxiety and depression symptoms will be based on 5 validated instruments. The 5 validated instruments are: Tinnitus Functional Index (TFI), Amsterdam Misophonia Scale (A-MIS-S), Pediatric Quality of Life PEDQL), Screen for Child Anxiety Related Emotional Disorders (SCARED) and Short Mood and Feelings Questionnaire (SMFQ).

      Trial Details

      Trial Status:Recruiting
      Trial Phase:Unphased
      Age:10 - 18

      Key Eligibility Criteria

      Disqualifiers:Severe Developmental Delay, Visual Impairment, Hearing Loss, Seizure Disorder

      30 Participants Needed

      Therapeutic Hypothermia for Tinnitus

      Bozeman, Montana
      The goal of this remote interventional clinical study is to investigate the use of mild therapeutic hypothermia devices for the symptomatic relief of chronic tinnitus. The main aims of the study are: 1. Ascertain the effects of MTH in chronic tinnitus patients using questionnaires measuring tinnitus severity and intervention-related change. 2. Ascertain the comfort and acceptability of the hypothermia device and therapy. Participants with chronic tinnitus will wear the mild therapeutic hypothermia therapy devices for a single 30 minute session. Researchers will compare results from those receiving therapy to those from a control group.

      Trial Details

      Trial Status:Recruiting
      Trial Phase:Unphased
      Age:18 - 55

      Key Eligibility Criteria

      Disqualifiers:Vertigo, Menière's, Otitis, Raynaud's, Others

      80 Participants Needed

      Neuromodulation and Listening Therapy for Tinnitus

      Tucson, Arizona
      The goal of this study is to use non-invasive transcranial direct current stimulation (tDCS) combined with active listening therapy to treat tinnitus and hyperacusis and related conditions.

      Trial Details

      Trial Status:Not Yet Recruiting
      Trial Phase:Unphased

      Key Eligibility Criteria

      Disqualifiers:Neurological Disorders, Epilepsy, Meniere's, Others

      30 Participants Needed

      Migraine Medications for Tinnitus

      Orange, California
      Tinnitus represents one of the most common and distressing otologic problems, and it causes various somatic and psychological disorders that interfere with the quality of life. Despite too many research projects on finding the mechanism of tinnitus, its pathophysiology remains poorly understood. It is well understood that many factors, such as poor education, lower income, or occupational, and recreational activity associated with high noise exposure, influence the prevalence and risk of tinnitus. Although the economic and emotional impact of tinnitus is large, there is currently no FDA-approved medication to treat this condition. However, there are pharmacological options to address the stress, anxiety, and depression that are caused by tinnitus. In this project, the investigators intend to use medications for patients with acute tinnitus to decrease the impact of tinnitus in their daily lives and activities. There are some studies on medications treating tinnitus; however, there are few randomized clinical trials to prove the efficacy of the treatment. The frequency and loudness of tinnitus will be measured before and after the course. Functional MRI of the brain will be obtained to view any changes that may occur before and after the treatment.
      No Placebo Group

      Trial Details

      Trial Status:Active Not Recruiting
      Trial Phase:Phase 4
      Age:25 - 85

      Key Eligibility Criteria

      Disqualifiers:Pregnancy, Adverse Medication Reaction, Others

      100 Participants Needed

      Acoustic + Electrical Stimulation for Tinnitus

      Irvine, California
      This trial is testing if playing sounds through headphones or using small electrical currents in the ear can help people with tinnitus. It targets those whose tinnitus significantly affects their quality of life. The treatment works by trying to interfere with the ringing noise, making it quieter or stopping it. Using small electrical currents has been explored in various studies as a potential treatment for tinnitus, showing mixed results in terms of effectiveness.
      No Placebo Group

      Trial Details

      Trial Status:Active Not Recruiting
      Trial Phase:Unphased

      Key Eligibility Criteria

      Disqualifiers:Illicit Drug Use, Alcohol Dependence, Psychosis, Others
      Must Not Be Taking:Aspirin, Ibuprofen, Naproxen

      100 Participants Needed

      Multimodal Therapy for Tinnitus

      Portland, Oregon
      The purpose of this study is to learn more about a type of tinnitus (ringing in the ears) known as "somatosensory tinnitus." This type of tinnitus is suspected when the tinnitus perception changes following head and/or neck movements. This study is also exploring a possible way to treat somatosensory tinnitus.
      No Placebo Group

      Trial Details

      Trial Status:Recruiting
      Trial Phase:Unphased

      Key Eligibility Criteria

      Disqualifiers:Middle Ear Pathology, Orofacial Pathology, Others

      72 Participants Needed

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      We started Power when my dad was diagnosed with multiple myeloma, and I struggled to help him access the latest immunotherapy. Hopefully Power makes it simpler for you to explore promising new treatments, during what is probably a difficult time.

      Bask
      Bask GillCEO at Power
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      Frequently Asked Questions

      How much do Tinnitus clinical trials pay?

      Each trial will compensate patients a different amount, but $50-100 for each visit is a fairly common range for Phase 2–4 trials (Phase 1 trials often pay substantially more). Further, most trials will cover the costs of a travel to-and-from the clinic.

      How do Tinnitus clinical trials work?

      After a researcher reviews your profile, they may choose to invite you in to a screening appointment, where they'll determine if you meet 100% of the eligibility requirements. If you do, you'll be sorted into one of the treatment groups, and receive your study drug. For some trials, there is a chance you'll receive a placebo. Across Tinnitus trials 30% of clinical trials have a placebo. Typically, you'll be required to check-in with the clinic every month or so. The average trial length for Tinnitus is 12 months.

      How do I participate in a study as a "healthy volunteer"?

      Not all studies recruit healthy volunteers: usually, Phase 1 studies do. Participating as a healthy volunteer means you will go to a research facility several times over a few days or weeks to receive a dose of either the test treatment or a "placebo," which is a harmless substance that helps researchers compare results. You will have routine tests during these visits, and you'll be compensated for your time and travel, with the number of appointments and details varying by study.

      What does the "phase" of a clinical trial mean?

      The phase of a trial reveals what stage the drug is in to get approval for a specific condition. Phase 1 trials are the trials to collect safety data in humans. Phase 2 trials are those where the drug has some data showing safety in humans, but where further human data is needed on drug effectiveness. Phase 3 trials are in the final step before approval. The drug already has data showing both safety and effectiveness. As a general rule, Phase 3 trials are more promising than Phase 2, and Phase 2 trials are more promising than phase 1.

      Do I need to be insured to participate in a Tinnitus medical study?

      Clinical trials are almost always free to participants, and so do not require insurance. The only exception here are trials focused on cancer, because only a small part of the typical treatment plan is actually experimental. For these cancer trials, participants typically need insurance to cover all the non-experimental components.

      What are the newest Tinnitus clinical trials?

      Most recently, we added Osteopathic Manipulative Treatment for Throwing Performance, Lenire Device for Tinnitus and Ebselen for Menière's Disease to the Power online platform.

      Are there trials for tinnitus?

      Yes—well over 100 clinical studies for tinnitus (from quick online surveys to device or medication trials) are recruiting worldwide. The fastest way to see what’s open is to type “tinnitus” into ClinicalTrials.gov or the WHO international registry and filter for “recruiting,” then contact the listed study team or ask your ENT/audiologist if you meet their inclusion rules. Before signing up, weigh the possible benefits against travel, time, and the chance of receiving a placebo, and be sure to read the informed-consent form carefully.

      What is the simple trick to stop tinnitus?

      There is no single “simple trick” that reliably switches tinnitus off, but you can make it less intrusive by calming your body and giving your ears something else to focus on: try slow belly-breathing, add gentle background sound (fan, soft music, white-noise app), and relax tight neck-jaw muscles. If the ringing is new, one-sided, pulsates with your heartbeat, or comes with sudden hearing loss, see a doctor promptly; otherwise, longer-term relief often comes from structured programs such as cognitive-behavioural therapy, sound therapy, or hearing aids that address both the noise and the stress it causes.

      At what point is tinnitus permanent?

      Doctors label tinnitus “chronic” once it has persisted for about six months; after that point it rarely goes away on its own, although many people can still reduce how much it bothers them with treatment. Ringing that begins after loud noise or an ear infection usually settles within minutes, days, or at most a few weeks—so if yours lasts longer than two weeks, or is paired with new hearing loss, see an audiologist or ENT promptly to look for reversible causes and start proven coping strategies before it becomes long-term.

      Has anyone reversed tinnitus?

      Yes—tinnitus can and does disappear for some people, especially when the underlying cause (e.g., ear-wax, middle-ear infection, medication side-effect, sudden hearing loss or jaw/neck problems) is found and fixed, and about 1 in 5 new cases fade on their own within a year. Even when it persists, most patients can make it much less intrusive by combining ear-focused measures (hearing aids, sound or masking devices) with brain-focused approaches like cognitive-behavioural therapy or tinnitus-retraining therapy, so the key first step is a thorough exam by an ENT/audiologist to look for reversible triggers and then choose the right management tools.

      What is the drug of choice for tinnitus?

      There is actually no single “drug of choice” for tinnitus—no medicine has been proven to reliably silence the ringing, and any drug use is off-label and aimed at easing related problems such as anxiety, depression, or poor sleep. Doctors first recommend non-drug strategies (hearing aids, background sound generators, cognitive-behavioral therapy) and then may trial medicines like a tricyclic antidepressant (e.g., nortriptyline), a benzodiazepine (e.g., clonazepam), or gabapentin in selected patients who are very distressed, monitoring closely for side-effects. Work with an ENT or audiologist to create a plan that addresses both the noise and its emotional impact rather than relying on a single pill.

      Is tinnitus a legal disability?

      Tinnitus can qualify as a legal disability when the ringing is severe enough to limit your ability to work or perform major life activities, but the exact test depends on the system making the decision. For Social Security (SSDI/SSI) you must show medical proof of the condition and that it stops you from “substantial gainful activity” for at least 12 months; under the ADA the same medical evidence can trigger workplace accommodations; and the VA automatically grants a 10 % rating if the tinnitus is service-connected, with higher benefits possible if it prevents employment. In every case, detailed ENT or audiology records, treatment history, and statements describing how the noise affects concentration, sleep, balance, or communication are what turn tinnitus from a symptom into a legally recognized disability.

      Do tinnitus ear drops work?

      Off-the-shelf “tinnitus ear drops” have never been shown in good studies to quiet chronic ringing, and standard prescription drops help only when they treat a reversible ear problem—think wax blockage or an outer-ear infection that is causing or amplifying the noise. If the tinnitus comes from inner-ear damage or brain pathways (the usual case), drops won’t work; proven relief instead comes from strategies like hearing aids, sound therapy, or tinnitus-focused CBT after an ENT or audiology evaluation. Seek prompt medical review if the ringing is one-sided, pulsating, or tied to sudden hearing loss, and avoid unregulated drops that can irritate the canal.

      Is tinnitus hard to prove?

      Most tinnitus is “subjective,” meaning only you can hear it, so a doctor can’t capture the sound itself—but they can still document it by showing related hearing changes on an audiogram, matching the pitch/loudness of the ringing, and scoring its impact with validated questionnaires such as the Tinnitus Handicap Inventory. This bundle of test results is usually enough for a formal diagnosis and for insurance or disability claims; only in the uncommon “objective” form can a clinician actually hear the noise through a stethoscope or microphone.

      What is the new cure for tinnitus?

      There is still no permanent cure for tinnitus, but the newest FDA-cleared treatment is Lenire, a headset that pairs tailored sounds with gentle electrical pulses to the tongue; in a 326-person randomized study, about 70 % of users had a meaningful drop in symptom scores after 12 weeks, and benefits often persisted for a year with minimal side effects. Results vary—ringing rarely disappears completely—so specialists still rely on hearing aids, sound-therapy apps, and cognitive-behavioral techniques when Lenire isn’t available or sufficient. Discuss the pros, cost, and suitability of each option with an ENT or audiologist to decide what’s realistic for you.